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Prague River Cruise Departures

River Cruises that depart from Europe: Czech Republic: Prague

River Cruises that visit Prague

See all Cruises that depart from Prague

Vltava River Cruises

Click on a cruise ship itinerary sailing from Prague (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Prague), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Prague
Shore Excursions

Avalon Waterways Tours, Avalon Tranquility II Tours
Avalon Tranquility II Tours7 Night - Christmastime in the Heart of Germany with in Prague
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt (Disembarkation)
2026 Sails: Dec 9, More...
Avalon Waterways Tours, Avalon Vista Tours
Avalon Vista Tours8 Night - Christmastime On the Danube with in Prague (Eastbound)
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2026 Sails: Dec 9, More...
AmaWaterways Tours, AmaVerde Tours
AmaVerde Tours10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 11, 2027: Dec 17, More...
Avalon Waterways Tours, Avalon Illumination Tours
Avalon Illumination Tours11 Night - Christmastime from Nuremberg to Basel with in Prague
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt Excursion to Rudesheim, Speyer Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation)
2026 Sails: Dec 11, More...
Avalon Waterways Tours, Avalon Illumination Tours
Avalon Illumination Tours7 Night - Christmastime in the Heart of Germany with in Prague
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Bamberg, Wurzburg, Miltenberg, Frankfurt (Disembarkation)
2026 Sails: Dec 11, More...
Scenic Luxury, Scenic Amber
Scenic Amber10 Night - Danube Christmas Markets with Prague
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Brandstatt / Passau, Regensburg
2026 Sails: Dec 11, More...
Avalon Waterways Tours, Avalon Expression Tours
Avalon Expression Tours8 Night - Christmastime On the Danube with in Prague (Eastbound)
Starting in Prague, Czech Republic, Prague, Prague / Nuremberg, Germany (Embarkation), Nuremberg, Regensburg, Passau, Melk, Austria, Vienna, Vienna (Disembarkation)
2026 Sails: Dec 12, More...
Scenic Luxury, Scenic Opal
Scenic Opal10 Night - Gems of the Danube with Prague
Starting in Prague, Prague / Regensburg, Regensburg, Passau / Schlogen, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Dec 12, 2027: Sep 25, Oct 9, Dec 11, More...
AmaWaterways Tours, AmaSonata Tours
AmaSonata Tours10 Night - Iconic Christmas Markets with Prague Pre-Cruise
Starting in Prague, Nuremberg, Regensburg, Passau, Melk, Vienna, Budapest
2026 Sails: Dec 13, 2027: Dec 5, More...
Scenic Luxury, Scenic Pearl
Scenic Pearl10 Night - Danube Christmas Markets with Prague
Starting in Prague, Prague / Regensburg, Regensburg, Passau / Schlogen, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Dec 13, More...

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Prague River Cruise Departures