South Carolina Cruises

Cruises that visit North America: United States: South Carolina

Cruises that depart from South Carolina

See all River Cruises that visit South Carolina

Click on a cruise ship itinerary that visits South Carolina (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South Carolina), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Beaufort : Charleston : Hilton Head Island

Regent Seven Seas Cruises, Seven Seas Mariner

16 Night - Spotlight with Southern Living
Starting in Miami, Cruising the Old Bahama Channel, Cruising the Caribbean Sea, Oranjestad, Willemstad AN, Bonaire (Kralendijk), St Georges, Castries, Gustavia, San Juan, Cruising the Atlantic Ocean, Charleston, Cruising the Atlantic Ocean, New York
2026 Sails: Jun 13, More...

Oceania Cruises, Oceania Vista

Deal link -> Special

22 Night - Gaelic & Icelandic Sagas
Starting in London (Southampton), Falmouth (Cornwall), Dublin (Dun Laoghaire), Cork (Cobh), Belfast, Glasgow (Greenock), Torshavn, Faroe Islands, Akureyri, Isafjordur, Reykjavik, Halifax, New York, Charleston, Miami
2026 Sails: Jun 14, More...

Norwegian Cruise Tours, Norwegian Jewel Cruise Tours

11 Night - Pre Philadelphia Cruisetour
Starting in At Hotel, Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 25, More...

Norwegian Cruise Line, Norwegian Jewel

9 Night - Bermuda
Starting in Philadelphia, Pa, Royal Naval Dockyard, Bermuda, Charleston, SC, Philadelphia, Pa
2026 Sails: Aug 27, More...

Viking Ocean, Viking Octantis

14 Night - Canada & East Coast Explorer
Starting in Toronto, Ontario, Scenic Sailing St Lawrence Seaway Locks, Trois-Rivieres, Quebec, Quebec City, Quebec, Scenic Sailing St Lawrence River, Cap-Aux-Meules, Quebec, Cape Breton Island (Louisbourg), Nova Scotia, Lunenburg, Nova Scotia, Sail the Atlantic Ocean, Norfolk, Virginia, Sail the Atlantic Ocean, Charleston, South Carolina, Sail the Atlantic Ocean, Fort Lauderdale, Florida
2026 Sails: Oct 9, More...

Princess Cruise Tours, Sapphire Princess Cruise Tours

19 Night - Maple Explorer - Tour 2B
Starting in Toronto, Canada, Ottawa, Canada, Montebello, Canada, Montreal, Canada, Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, Boston, Massachusetts, Newport, Rhode Island, New York City (Manhattan or Brooklyn), New York, Charleston, South Carolina, Fort Lauderdale, Florida
2026 Sails: Oct 18, More...

Princess Cruises, Sapphire Princess

14 Night - Canada & Colonial America
Starting in Quebec City, Canada, Saguenay, Canada, Charlottetown, Canada, Sydney CA, Halifax, Canada, Boston, Massachusetts, Newport, Rhode Island, New York City (Manhattan or Brooklyn), New York, Charleston, South Carolina, Fort Lauderdale, Florida
2026 Sails: Oct 23, More...

American Cruise Lines, American Liberty

14 Night - East Coast Inland Passage Cruise
Starting in Baltimore, MD, St Michaels, MD, Norfolk, Va, Kitty Hawk, NC, Beaufort, NC / Morehead City, NC, Wilmington, NC, Day of Cruising, Charleston, SC, Beaufort, SC, Hilton Head, SC, Savannah, GA, St Simons Island, GA, Jekyll Island, GA, Fernandina Beach, FL, Amelia Island, FL
2026 Sails: Oct 27, More...

American Cruise Lines, American Glory

American Cruise Lines, American Eagle

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