Santo Tomas de Castilla Cruises
Cruises that visit Central America: Guatemala: Santo Tomas de Castilla
10 Night - Passage to Panama
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2026 Sails: Jan 17, More...
12 Night - Mesoamerican Majesty
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Roatan, Santo Tomas, Belize City, Montego Bay, George Town, Miami
2026 Sails: Jan 28, More...
12 Night - Caribbean Flavors & Cozumel
Starting in Miami, Key West, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas De Castilla, Harvest Caye, Roatan, Cruising the Caribbean Sea, Ocho Rios, Jamaica, George Town, Cruising the Florida Straits, Miami
2026 Sails: Mar 14, More...21 Night - Atlantic Ocean Isles
Starting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2026 Sails: Nov 8, More...
13 Night - The Americas & Caribbean
Starting in Fort Lauderdale, New Orleans, Cozumel, Quintana Roo, Roatan Island, Santo Tomas, Montego Bay, George Town (Grand Cayman), Fort Lauderdale
2026 Sails: Nov 11, More...7 Night - Fall for the Caribbean
Starting in Miami, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2026 Sails: Nov 22, More...
18 Night - An Extended Journey of Historic Echoes & Ocean Breezes
Starting in Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Nov 25, More...15 Night - An Extended Journey of Cultural Treasures & Seaside Harmony
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami, St John VI (Cruz Bay), US Virgin Islands, St Johns AG, Antigua, Terre-De-Haut, St Maarten / Philipsburg, San Juan
2026 Sails: Dec 5, More...8 Night - A Journey Into Tropical Idylls & Mayan Mystery
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Dec 5, More...21 Night - The Americas & Caribbean
Starting in Fort Lauderdale, St Thomas, Virgin Gorda, St Johns, San Juan, Samana, Nassau (Paradise Island), Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 20, More...
Cruises that visit Central America: Guatemala: Santo Tomas de Castilla
Click on a cruise ship itinerary that visits Santo Tomas de Castilla (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Tomas de Castilla), please visit: Cruise Search or try our Virtual Cruise Advisor™.
10 Night - Passage to PanamaStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2026 Sails: Jan 17, More...
12 Night - Mesoamerican MajestyStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Roatan, Santo Tomas, Belize City, Montego Bay, George Town, Miami
2026 Sails: Jan 28, More...
Deal link -> Special
12 Night - Caribbean Flavors & CozumelStarting in Miami, Key West, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas De Castilla, Harvest Caye, Roatan, Cruising the Caribbean Sea, Ocho Rios, Jamaica, George Town, Cruising the Florida Straits, Miami
2026 Sails: Mar 14, More...
21 Night - Atlantic Ocean IslesStarting in Rome (Civitavecchia), Cruising the Mediterranean Sea, Palma De Mallorca, Cruising the Gibraltar Straight, Cruising the Atlantic Ocean, Funchal (Madeira), Cruising the Atlantic Ocean, Royal Naval Dockyard, Cruising the Atlantic Ocean, Miami, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2026 Sails: Nov 8, More...
13 Night - The Americas & CaribbeanStarting in Fort Lauderdale, New Orleans, Cozumel, Quintana Roo, Roatan Island, Santo Tomas, Montego Bay, George Town (Grand Cayman), Fort Lauderdale
2026 Sails: Nov 11, More...
7 Night - Fall for the CaribbeanStarting in Miami, Cruising the Caribbean Sea, Roatan, Harvest Caye, Santo Tomas De Castilla, Costa Maya, Mexico, Cruising the Straits of Florida, Miami
2026 Sails: Nov 22, More...
18 Night - An Extended Journey of Historic Echoes & Ocean BreezesStarting in Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Nov 25, More...
15 Night - An Extended Journey of Cultural Treasures & Seaside HarmonyStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami, St John VI (Cruz Bay), US Virgin Islands, St Johns AG, Antigua, Terre-De-Haut, St Maarten / Philipsburg, San Juan
2026 Sails: Dec 5, More...
8 Night - A Journey Into Tropical Idylls & Mayan MysteryStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Dec 5, More...
21 Night - The Americas & CaribbeanStarting in Fort Lauderdale, St Thomas, Virgin Gorda, St Johns, San Juan, Samana, Nassau (Paradise Island), Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 20, More...
