Santo Tomas de Castilla Cruises
Cruises that visit Central America: Guatemala: Santo Tomas de Castilla
8 Night - A Journey Into Tropical Idylls & Mayan Mystery
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Dec 5, More...
21 Night - The Americas & Caribbean
Starting in Fort Lauderdale, St Thomas, Virgin Gorda, St Johns, San Juan, Samana, Nassau (Paradise Island), Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 20, More...
11 Night - Azure Elegance
Starting in Miami, Cruising the Florida Straits, Progreso, Cruising the Caribbean Sea, Santo Tomas De Castilla, Harvest Caye, Roatan, Cruising the Caribbean Sea, Falmouth, George Town, Cruising the Straits of Florida, Miami
2026 Sails: Dec 28, More...
14 Night - Blue Seas & Pastel Towns
Starting in Galveston, Cruising the Gulf, Cozumel, Mexico, Belize City, Santo Tomas De Castilla, Roatan, Cruising the Caribbean Sea, Montego Bay, Cruising the Caribbean Sea, Willemstad AN, Oranjestad, Bonaire (Kralendijk), Cruising the Caribbean Sea, Cruising the Atlantic Ocean, Miami
2026 Sails: Dec 28, More...11 Night - The Americas & Caribbean
Starting in Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 30, More...
20 Night - Panama Canal & Caribbean
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...10 Night - Panama Potpourri
Starting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...18 Night - An Extended Journey of Coastal Marvels & Caribbean Dreams
Starting in Miami, Puerto Plata, Dominican Republic, Cayo Levantado, Dominican Republic, San Juan, Charlotte Amalie (Saint Thomas), Spanish Town (Virgin Gorda), Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami
2027 Sails: Jan 11, More...9 Night - A Journey of Enchanting Ancient History & Coastal Splendour
Starting in Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami
2027 Sails: Jan 20, More...16 Night - An Extended Journey Through Ancient Marvels & Glittering Shores
Starting in Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami, Puerto Plata, Dominican Republic, St Maarten / Philipsburg, Terre-De-Haut, Basseterre, San Juan
2027 Sails: Jan 20, More...
Cruises that visit Central America: Guatemala: Santo Tomas de Castilla
Click on a cruise ship itinerary that visits Santo Tomas de Castilla (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santo Tomas de Castilla), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Deal link -> Special
8 Night - A Journey Into Tropical Idylls & Mayan MysteryStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Santo Tomas, Belize City, Roatan Island, Miami
2026 Sails: Dec 5, More...
21 Night - The Americas & CaribbeanStarting in Fort Lauderdale, St Thomas, Virgin Gorda, St Johns, San Juan, Samana, Nassau (Paradise Island), Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 20, More...
11 Night - Azure EleganceStarting in Miami, Cruising the Florida Straits, Progreso, Cruising the Caribbean Sea, Santo Tomas De Castilla, Harvest Caye, Roatan, Cruising the Caribbean Sea, Falmouth, George Town, Cruising the Straits of Florida, Miami
2026 Sails: Dec 28, More...
Deal link -> Special
14 Night - Blue Seas & Pastel TownsStarting in Galveston, Cruising the Gulf, Cozumel, Mexico, Belize City, Santo Tomas De Castilla, Roatan, Cruising the Caribbean Sea, Montego Bay, Cruising the Caribbean Sea, Willemstad AN, Oranjestad, Bonaire (Kralendijk), Cruising the Caribbean Sea, Cruising the Atlantic Ocean, Miami
2026 Sails: Dec 28, More...
11 Night - The Americas & CaribbeanStarting in Fort Lauderdale, Cozumel, Quintana Roo, Belize City, Santo Tomas, Roatan Island, George Town (Grand Cayman), Ocho Rios, Jamaica, Nassau (Paradise Island), Fort Lauderdale
2026 Sails: Dec 30, More...
20 Night - Panama Canal & CaribbeanStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City, Panama Canal Daylight Transit, Cartagena CO, Santa Marta, Oranjestad, Willemstad AN, Ocho Rios, Jamaica, George Town, Miami
2027 Sails: Jan 5, More...
10 Night - Panama PotpourriStarting in Miami, Cozumel, Mexico, Costa Maya, Mexico, Harvest Caye, Santo Tomas, Roatan, Puerto Limon, Panama Canal Daylight Transit, Panama City
2027 Sails: Jan 5, More...
Deal link -> Special
18 Night - An Extended Journey of Coastal Marvels & Caribbean DreamsStarting in Miami, Puerto Plata, Dominican Republic, Cayo Levantado, Dominican Republic, San Juan, Charlotte Amalie (Saint Thomas), Spanish Town (Virgin Gorda), Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami
2027 Sails: Jan 11, More...
Deal link -> Special
9 Night - A Journey of Enchanting Ancient History & Coastal SplendourStarting in Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami
2027 Sails: Jan 20, More...
16 Night - An Extended Journey Through Ancient Marvels & Glittering ShoresStarting in Miami, Ocho Rios, Jamaica, Santo Tomas, Roatan Island, Belize City, Key West, Miami, Puerto Plata, Dominican Republic, St Maarten / Philipsburg, Terre-De-Haut, Basseterre, San Juan
2027 Sails: Jan 20, More...
