South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
18 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 15, More...
17 Night - Msc Grand Voyages
Starting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 15, More...16 Night - Msc Grand Voyages
Starting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 15, More...
4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...16 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...15 Night - Msc Grand Voyages
Starting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 16, More...
18 Night - An Extended Journey Through Caribbean Beauty & Ocean Stillness
Starting in Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 17, More...
17 Night - The Great Austral Loop
Starting in Ushuaia, Grave Cove, The Neck, Saunders Island, South Georgia, Antarctic Peninsula, Crossing the Drake Passage, Ushuaia
2026 Sails: Nov 17, More...
31 Night - Panama Canal, Inca & South America : Chilean Fjords
Starting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, San Antonio CL (Santiago), Chile, Puerto Montt, Chile, Puerto Chacabuco, Chile, Cruising Chilean Fjords, Pio XI Glacier (Bruggen Glacier), Chile, Scenic cruising Sarmiento Channel, Strait of Magellan, Punta Arenas, Chile, Cockburn Channel, Beagle Channel, Daylight cruising Glacier Alley, Ushuaia, Argentina, Scenic Cruising Cape Horn, Port Stanley, Falkland Islands, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 18, More...16 Night - Inca & Panama Canal Discovery : Lima Overnight
Starting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, San Antonio CL (Santiago), Chile
2026 Sails: Nov 18, 2027: Nov 16, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
18 Night - Msc Grand VoyagesStarting in Barcelona, Spain, Gibraltar, Casablanca (Marrakesh), Morocco, Las Palmas de Gran Canaria (Canary Islands), Spain, Maceio, Brazil, Salvador, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 15, More...
17 Night - Msc Grand VoyagesStarting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 15, More...
16 Night - Msc Grand VoyagesStarting in Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 15, More...
4 Night - South AmericaStarting in Santos (Sao Paulo), Brazil, Ilha Grande, Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...
16 Night - Msc Grand VoyagesStarting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Nov 16, More...
15 Night - Msc Grand VoyagesStarting in Barcelona, Spain, Funchal (Madeira Islands), Portugal, Las Palmas de Gran Canaria (Canary Islands), Spain, Santa Cruz de Tenerife, Salvador, Brazil, Rio De Janeiro, Brazil
2026 Sails: Nov 16, More...
18 Night - An Extended Journey Through Caribbean Beauty & Ocean StillnessStarting in Miami, Merida (Progreso), Roatan Island, Belize City, Ocean Cay, Miami, Willemstad AN, Oranjestad, Santa Marta, Cartagena CO, George Town, Grand Cayman, Miami
2026 Sails: Nov 17, More...
17 Night - The Great Austral LoopStarting in Ushuaia, Grave Cove, The Neck, Saunders Island, South Georgia, Antarctic Peninsula, Crossing the Drake Passage, Ushuaia
2026 Sails: Nov 17, More...
31 Night - Panama Canal, Inca & South America : Chilean FjordsStarting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, San Antonio CL (Santiago), Chile, Puerto Montt, Chile, Puerto Chacabuco, Chile, Cruising Chilean Fjords, Pio XI Glacier (Bruggen Glacier), Chile, Scenic cruising Sarmiento Channel, Strait of Magellan, Punta Arenas, Chile, Cockburn Channel, Beagle Channel, Daylight cruising Glacier Alley, Ushuaia, Argentina, Scenic Cruising Cape Horn, Port Stanley, Falkland Islands, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 18, More...
16 Night - Inca & Panama Canal Discovery : Lima OvernightStarting in Fort Lauderdale, Florida, Georgetown, Cayman Islands, Enter Panama Canal Cristobal, Cruising Panama Canal, Exit Panama Canal Balboa, Fuerte Amador, Panama, Crossing the Equator, Manta, Ecuador, Salaverry (Trujillo), Peru, Callao (Lima), Peru, General San Martin (Pisco), Peru, Coquimbo (La Serena), Chile, San Antonio CL (Santiago), Chile
2026 Sails: Nov 18, 2027: Nov 16, More...
