South America Cruises
Cruises that visit South America
Cruises by region
See all South America River Cruises
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
91 Night - Msc World Cruise
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore
2026 Sails: Jan 5, More...78 Night - Msc World Cruise
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan
2026 Sails: Jan 5, More...32 Night - Msc World Cruise
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles
2026 Sails: Jan 5, More...
22 Night - Panama Canal - Ocean to Ocean
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Honolulu, Hawaii
2026 Sails: Jan 5, More...131 Night - Circle Pacific - Ft. Lauderdale to Los Angeles
Starting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Honolulu, Hawaii, Kauai (Nawiliwili), Hawaii, Kahului, Hawaii, Kona, Hawaii, Raiatea, French Polynesia, Moorea, French Polynesia, Tahiti (Papeete), French Polynesia, Cross International Date Line, Apia, Western Samoa, Suva, Fiji, Dravuni Island, Fiji, Port Vila, Vanuatu, Lifou, New Caledonia, Auckland, New Zealand, Tauranga, New Zealand, Picton, New Zealand, New Plymouth, New Zealand, Fiordland National Park (Scenic Cruising), Sydney AU, Burnie, Australia, Melbourne, Australia, Adelaide, Australia, Perth (Fremantle), Australia, Bali (Benoa), Indonesia, Kuala Lumpur (Port Kelang), Malaysia, Penang, Malaysia, Singapore, Ko Samui, Thailand, Laem Chabang (for Bangkok), Thailand, Ho Chi Minh City (Phu My), Vietnam, Cam Ranh (Nha Trang), Vietnam, Halong Bay / Hanoi (Cai Lan), Vietnam, Scenic Cruising Halong Bay, Da Nang / Hue (Chan May), Vietnam, Hong Kong, Taipei (Keelung), Jeju (Seogwipo), South Korea, Yatsushiro, Japan, Kagoshima, Japan, Kochi, Japan, Osaka (for Kyoto), Japan, Shimizu (for Mount Fuji), Japan, Tokyo (Yokohama), Japan, Miyako, Japan, Aomori, Japan, Hakodate, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: Jan 5, More...
12 Night - Antarctic Explorer
Starting in Buenos Aires, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing : Cape Horn, Ushuaia
2026 Sails: Jan 5, More...
15 Night - Mexico, Panama & Peru Cruise : Progreso, Panama Canal & Lima
Starting in Miami, Florida, Progreso, Bocas del Toro, Panama Canal (Cruising), Panama City (Fuerte Amador), Manta, Guayaquil, Salaverry (Trujillo), Callao (Lima)
2026 Sails: Jan 6, More...
8 Night - South America Roundtrip from Montevideo
Starting in Montevideo, Camboriu, Brazil, Ilhabela, Rio De Janeiro, Buenos Aires, Montevideo
2026 Sails: Jan 6, More...
6 Night - Galapagos Escape : a Voyage
Starting in Guayaquil or Quito, Ecuador, Quito or Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Quito or Guayaquil
2026 Sails: Jan 6, Jan 20, Feb 3, Feb 17, Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, May 26, Jun 9, Jun 23, Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, Oct 27, Nov 10, Nov 24, More...
11 Night - Voyage to Antarctica
Starting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Jan 6, Jan 16, Nov 26, Dec 6, Dec 16, Dec 26, 2027: Jan 5, Feb 7, Oct 15, Oct 25, Nov 4, Nov 28, Dec 8, Dec 18, Dec 28, 2028: Jan 21, Feb 23, Mar 4, More...
Cruises that visit South America
Cruises by region
See all South America River Cruises
Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.
Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Suriname : Uruguay
91 Night - Msc World CruiseStarting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan, Nagasaki, Japan, Busan, South Korea, Shanghai, China, Hong Kong, China, Da Nang, Vietnam, Singapore
2026 Sails: Jan 5, More...
78 Night - Msc World CruiseStarting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles, Hilo, Hawaii, Pago Pago, American Samoa, Apia, Western Samoa, Suva, Fiji, Auckland, New Zealand, Wellington, New Zealand, Sydney AU, Australia, Townsville, Australia, Cairns, Australia, Manila, Philippines, Keelung (Taipei) Taiwan, China, Ishigaki, Japan, Naha (Okinawa), Japan, Tokyo, Japan
2026 Sails: Jan 5, More...
32 Night - Msc World CruiseStarting in Genoa (Portofino), Italy, Marseille (Provence), France, Barcelona, Spain, Funchal (Madeira Islands), Portugal, Bridgetown, Barbados, Saint George, Grenada, Willemstad AN, Curacao, Cartagena CO, Puerto Limon, Costa Rica, Cruising Panama Canal, Puntarenas (San Jose), Costa Rica, Puerto Quetzal, Guatemala, Puerto Vallarta, Mexico, Cabo San Lucas, Mexico, San Diego, Los Angeles
2026 Sails: Jan 5, More...
22 Night - Panama Canal - Ocean to OceanStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Honolulu, Hawaii
2026 Sails: Jan 5, More...
131 Night - Circle Pacific - Ft. Lauderdale to Los AngelesStarting in Fort Lauderdale, Florida, Cartagena CO, Panama Canal Full Transit Historic Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California, Honolulu, Hawaii, Kauai (Nawiliwili), Hawaii, Kahului, Hawaii, Kona, Hawaii, Raiatea, French Polynesia, Moorea, French Polynesia, Tahiti (Papeete), French Polynesia, Cross International Date Line, Apia, Western Samoa, Suva, Fiji, Dravuni Island, Fiji, Port Vila, Vanuatu, Lifou, New Caledonia, Auckland, New Zealand, Tauranga, New Zealand, Picton, New Zealand, New Plymouth, New Zealand, Fiordland National Park (Scenic Cruising), Sydney AU, Burnie, Australia, Melbourne, Australia, Adelaide, Australia, Perth (Fremantle), Australia, Bali (Benoa), Indonesia, Kuala Lumpur (Port Kelang), Malaysia, Penang, Malaysia, Singapore, Ko Samui, Thailand, Laem Chabang (for Bangkok), Thailand, Ho Chi Minh City (Phu My), Vietnam, Cam Ranh (Nha Trang), Vietnam, Halong Bay / Hanoi (Cai Lan), Vietnam, Scenic Cruising Halong Bay, Da Nang / Hue (Chan May), Vietnam, Hong Kong, Taipei (Keelung), Jeju (Seogwipo), South Korea, Yatsushiro, Japan, Kagoshima, Japan, Kochi, Japan, Osaka (for Kyoto), Japan, Shimizu (for Mount Fuji), Japan, Tokyo (Yokohama), Japan, Miyako, Japan, Aomori, Japan, Hakodate, Japan, Cross International Date Line, Anchorage (Whittier), Alaska, Hubbard Glacier (Scenic Cruising), Alaska, Glacier Bay National Park (Scenic Cruising), Alaska, Skagway, Alaska, Juneau, Alaska, Sitka, Alaska, Ketchikan, Alaska, Victoria CA, Vancouver, Canada, Seattle, Washington, Astoria, Oregon, Santa Barbara, California, Ensenada, Mexico, San Diego, California, Los Angeles, California
2026 Sails: Jan 5, More...
12 Night - Antarctic ExplorerStarting in Buenos Aires, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing : Cape Horn, Ushuaia
2026 Sails: Jan 5, More...
15 Night - Mexico, Panama & Peru Cruise : Progreso, Panama Canal & LimaStarting in Miami, Florida, Progreso, Bocas del Toro, Panama Canal (Cruising), Panama City (Fuerte Amador), Manta, Guayaquil, Salaverry (Trujillo), Callao (Lima)
2026 Sails: Jan 6, More...
8 Night - South America Roundtrip from MontevideoStarting in Montevideo, Camboriu, Brazil, Ilhabela, Rio De Janeiro, Buenos Aires, Montevideo
2026 Sails: Jan 6, More...
6 Night - Galapagos Escape : a VoyageStarting in Guayaquil or Quito, Ecuador, Quito or Guayaquil / Galapagos Islands / Embark Ship, Galapagos Islands, Galapagos Islands / Disembark Ship / Guayaquil or Quito, Quito or Guayaquil
2026 Sails: Jan 6, Jan 20, Feb 3, Feb 17, Mar 3, Mar 17, Mar 31, Apr 14, Apr 28, May 12, May 26, Jun 9, Jun 23, Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, Oct 27, Nov 10, Nov 24, More...
11 Night - Voyage to AntarcticaStarting in Buenos Aires, Argentina or Santiago, Chile, Fly to Ushuaia, Argentina / Embark Ship, At Sea Crossing the Drake Passage, Antarctica, Ushuaia / Disembark Ship / Buenos Aires or Santiago
2026 Sails: Jan 6, Jan 16, Nov 26, Dec 6, Dec 16, Dec 26, 2027: Jan 5, Feb 7, Oct 15, Oct 25, Nov 4, Nov 28, Dec 8, Dec 18, Dec 28, 2028: Jan 21, Feb 23, Mar 4, More...
