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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



Viking Ocean Tours, Viking Polaris Tours
Viking Polaris Tours12 Night - Antarctic Explorer
Starting in Buenos Aires, Ushuaia, Sail the Drake Passage, Antarctica, Sail the Drake Passage, Scenic Sailing : Cape Horn, Ushuaia
2026 Sails: Dec 11, Dec 22, 2027: Jan 2, Jan 13, Jan 24, Feb 4, Feb 15, Feb 26, Nov 12, Dec 17, Dec 28, 2028: Jan 8, Jan 19, Jan 30, Feb 10, Feb 21, Mar 3, Mar 14, More...
Silversea, Silver Wind
Silver Wind10 Night - Puerto Williams to Puerto Williams
Starting in Puerto Williams, Drake Passage, Antarctic Sound, Antarctic Peninsula, South Shetland Islands, Drake Passage, Puerto Williams
2026 Sails: Dec 12, More...
Windstar, Star Legend
Star Legend8 Night - Panama Canal, Cartagena, San Blas Islands & More
Starting in Oranjestad, Cartagena CO, Bocas del Toro, San Blas, Panama, Panama Canal, Balboa / Fuerte Amador
2026 Sails: Dec 12, More...
Windstar, Star Legend
Star Legend16 Night - Star Collector : Latin America Explorer
Starting in Oranjestad, Cartagena CO, Bocas del Toro, San Blas, Panama, Panama Canal, Balboa / Fuerte Amador, Isla Partida, Golfo Dulce (Puerto Jimenez), Quepos, Punta Leona, Costa Rica, Curu, Costa Rica, Playa Flamingo, Puerto Caldera
2026 Sails: Dec 12, More...
MSC Cruises, MSC Musica
MSC Musica4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Ilha Grande, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 13, 2027: Mar 22, More...
MSC Cruises, MSC Poesia
MSC Poesia21 Night - Caribbean and Antilles
Starting in Miami, Florida, George Town, Cayman Islands, Ocho Rios, Jamaica, Willemstad AN, Kralendijk, Bonaire, Oranjestad, Aruba, Miami, Florida, Ocho Rios, Jamaica, Cartagena CO, Colon, Panama, Puerto Limon, Costa Rica, Isla De Roatan, Honduras, Belize, Miami, Florida
2026 Sails: Dec 13, More...
MSC Cruises, MSC Splendida
MSC Splendida8 Night - South America
Starting in Rio De Janeiro, Brazil, Ilhabela, Brazil, Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina, Rio De Janeiro, Brazil
2026 Sails: Dec 14, 2027: Feb 22, Mar 10, Mar 18, More...
MSC Cruises, MSC Divina
MSC Divina3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 15, Dec 26, More...
Viking Ocean, Viking Sea
Viking Sea21 Night - From the Caribbean to the Amazon
Starting in San Juan, Sail the Caribbean Sea, Bridgetown, Sail the Caribbean Sea, French Guiana (Iles Du Salut), Sail the Atlantic Ocean, Sail the Amazon River, Santarem, Parintins, Manaus, Sail the Amazon River, Belem, Sail the Atlantic Ocean, Scarborough, Castries, St Johns AG, Antigua, St Thomas (Charlotte Amalie), San Juan
2026 Sails: Dec 15, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa7 Night - South America
Starting in Maceio, Brazil, Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Maceio, Brazil
2026 Sails: Dec 16, 2027: Feb 24, More...

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South America Cruises