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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : Uruguay



MSC Cruises, MSC Seaview
MSC Seaview7 Night - South America
Starting in Buenos Aires, Argentina, Santos (Sao Paulo), Brazil, Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina
2026 Sails: Dec 24, Dec 31, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - South America
Starting in Paranagua, Brazil, Itajai, Brazil, Ilhabela, Brazil, Rio De Janeiro, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Copacabana (Rio de Janeiro), Brazil, Paranagua, Brazil
2026 Sails: Dec 26, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa7 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Copacabana (Rio de Janeiro), Brazil, Ilhabela, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 26, More...
Costa Cruise Lines, Costa Serena
Costa Serena9 Night - South America Roundtrip from Buenos Aires
Starting in Buenos Aires, Argentina, Montevideo, Uruguay, Camboriu, Brazil, Abraao (Ilha Grande), Rio de Janeiro, Brazil, Ilhabela, Brazil, Buenos Aires, Argentina
2026 Sails: Dec 27, More...
Holland America, Nieuw Amsterdam
Nieuw Amsterdam21 Night - Panama Canal & Southern Caribbean Holiday
Starting in Fort Lauderdale, Florida, RelaxAway, Half Moon Cay, Bahamas, Oranjestad, Aruba, Cartagena CO, Enter Panama Canal Cristobal, Cruising Panama Canal and Gatun Lake, Gatun Lake, Panama, Cruising Gatun Lake and Panama Canal, Exit Panama Canal Cristobal, Colon, Panama, Puerto Limon (San Jose), Costa Rica, Georgetown, Cayman Islands, Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Dec 27, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - South America
Starting in Itajai, Brazil, Ilhabela, Brazil, Rio De Janeiro, Brazil, Ilha Grande, Brazil, Buzios, Brazil, Copacabana (Rio de Janeiro), Brazil, Paranagua, Brazil, Itajai, Brazil
2026 Sails: Dec 27, More...
MSC Cruises, MSC Splendida
MSC Splendida9 Night - South America
Starting in Buenos Aires, Argentina, Ilhabela, Brazil, Rio De Janeiro, Brazil, Copacabana (Rio de Janeiro), Brazil, Ilha Grande, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina
2026 Sails: Dec 27, More...
Viking Ocean, Viking Mars
Viking Mars14 Night - Panama Canal & Central America
Starting in West Palm Beach, Florida, Sail the Caribbean Sea, Montego Bay, Sail the Caribbean Sea, Cartagena CO, Scenic Sailing Panama Canal, Colon, Puerto Limon, Sail the Caribbean Sea, Belize City, Cozumel, Mexico, Sail the Caribbean Sea, Fort Lauderdale, Florida
2026 Sails: Dec 27, More...
Costa Cruise Lines, Costa Serena
Costa Serena9 Night - South America Roundtrip from Montevideo
Starting in Montevideo, Uruguay, Camboriu, Brazil, Abraao (Ilha Grande), Rio de Janeiro, Brazil, Ilhabela, Brazil, Buenos Aires, Argentina, Montevideo, Uruguay
2026 Sails: Dec 28, More...
Scenic Luxury, Scenic Eclipse
Scenic Eclipse12 Night - Antarctica in Depth
Starting in Buenos Aires, Argentina, Buenos Aires / Ushuaia, Antarctica, At Sea / Ushuaia, Ushuaia, Argentina / Buenos Aires
2026 Sails: Dec 28, 2027: Nov 24, Dec 5, Dec 16, Dec 27, 2028: Jan 7, Jan 18, Jan 29, Feb 27, More...

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South America Cruises