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South America Cruises

Cruises that visit South America

Cruises by region

See all South America River Cruises

Click on a cruise ship itinerary in South America (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just South America), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Argentina : Brazil : Chile : Colombia : Ecuador : Falkland Islands / Malvinas : French Guiana : Peru : South Georgia / South Sandwich Islands : Uruguay



Celebrity Cruises, Celebrity Equinox
Celebrity Equinox14 Night - Patagonia & Argentina Cruise
Starting in Buenos Aires, Argentina, Montevideo, Uruguay, Port Stanley, Falkland Islands, Cape Horn, Chile, Ushuaia, Argentina, Strait of Magellan, Punta Arenas, Chile, Puerto Madryn, Argentina, Punta Del Este, Uruguay, Buenos Aires, Argentina
2026 Sails: Dec 5, Dec 19, 2027: Feb 13, Feb 27, Dec 5, 2028: Feb 13, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa7 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Maceio, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 5, Dec 12, Dec 19, 2027: Jan 2, Jan 9, Jan 16, Jan 23, Jan 30, Feb 13, Feb 20, Feb 27, Mar 6, Mar 13, Mar 20, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil, Maceio, Brazil
2026 Sails: Dec 5, 2027: Jan 2, More...
MSC Cruises, MSC Virtuosa
MSC Virtuosa3 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Salvador, Brazil
2026 Sails: Dec 5, More...
Princess Cruises, Caribbean Princess
Caribbean Princess12 Night - Caribbean with Costa Rica, Celebration Key & Panama Canal
Starting in Fort Lauderdale, Florida, Grand Cayman, Cayman Islands, Falmouth, Jamaica, Cartagena CO, Panama Canal Partial Transit New Locks, Colon, Panama, Limon, Costa Rica, Celebration Key, Bahamas, Fort Lauderdale, Florida
2026 Sails: Dec 5, More...
Star Clippers, Star Clipper
Star Clipper14 Night - Barbados to Panama
Starting in Bridgetown, Barbados, Tobago Cays, Grenadines, St Georges, Grenada, Kralendijk, Bonaire, Willemstad AN, Curacao, Oranjestad, Aruba, Santa Marta, Colombia, Cartagena De Indias, Colombia, San Blas Archipelago, Panama, Panama Canal Transit, Balboa (Isla Flamenco), Panama
2026 Sails: Dec 5, More...
MSC Cruises, MSC Musica
MSC Musica4 Night - South America
Starting in Santos (Sao Paulo), Brazil, Buzios, Brazil, Ilha Grande, Brazil, Santos (Sao Paulo), Brazil
2026 Sails: Dec 6, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - South Caribbean
Starting in Pointe-A-Pitre, Guadeloupe, St Johns AG, Antigua, Philipsburg, St Maarten, Basseterre, Sao Cristovao, Nevis, Roseau, Dominica, Fort-de-France, Martinique, Pointe-A-Pitre, Guadeloupe
2026 Sails: Dec 6, More...
MSC Cruises, MSC Splendida
MSC Splendida8 Night - South America
Starting in Rio De Janeiro, Brazil, Ilhabela, Brazil, Camboriu, Brazil, Punta Del Este, Uruguay, Buenos Aires, Argentina, Rio De Janeiro, Brazil
2026 Sails: Dec 6, More...
PONANT, Le Laperouse
Le Laperouse12 Night - Panama, Colombia & Caribbean Islands
Starting in Fort-de-France, Marie-Galante, Pigeon Island Beach, Soufriere, Union Island, Mayreau Island, Bonaire, Santa Marta, Cartagena, San Blas Islands, Portobelo, Colon
2026 Sails: Dec 7, More...

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South America Cruises