Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 5, More...

Viking Ocean, Viking Vela

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sete, Barcelona
2026 Sails: Dec 7, More...

Viking Ocean, Viking Neptune

14 Night - Ancient Mediterranean Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2026 Sails: Dec 8, More...

Viking Ocean, Viking Neptune

7 Night - Journey to Antiquities
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Sail the Ionian Sea, Crete (Souda Bay), Ephesus (Kusadasi), Athens (Piraeus)
2026 Sails: Dec 8, More...

Viking Ocean, Viking Libra

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Villefranche-Sur-Mer, Marseille, Sail the Mediterranean Sea, Barcelona
2026 Sails: Dec 20, More...

Regent Seven Seas, Seven Seas Navigator

14 Night - Spice Trail Sail
Starting in Rome (Civitavecchia), Naples / Pompeii, Messina (Sicily), Valletta, Cruising the Mediterranean Sea, Alexandria EG, Cruising the Mediterranean Sea, Limassol, Rhodes, Heraklion (Crete), Kusadasi, Athens (Piraeus)
2026 Sails: Dec 21, More...

Azamara Cruises, Azamara Onward

7 Night - Christmas Cruise : Florence, Mahon & Palma
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona
2026 Sails: Dec 22, More...

Azamara Cruises, Azamara Onward

17 Night - Mediterranean & Iberian New Year Cruise : Italy, Spain & Morocco
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Mahon, Menorca, Palma, Majorca, Barcelona, Cartagena ES, Malaga, Casablanca, Tangier, Cadiz, Seville, Lisbon
2026 Sails: Dec 22, More...

Viking Ocean, Viking Vesta

7 Night - Amalfi Coast, Africa & Iberia
Starting in Rome (Civitavecchia), Naples, Scenic Sailing Stromboli, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona
2026 Sails: Dec 23, More...

Viking Ocean, Viking Vesta

14 Night - Jewels of the Mediterranean
Starting in Rome (Civitavecchia), Naples, Scenic Sailing Stromboli, Tunis (La Goulette), Sardinia (Cagliari), Sail the Mediterranean Sea, Valencia, Barcelona, Marseille, Villefranche-Sur-Mer, Florence / Pisa (Livorno), Rome (Civitavecchia)
2026 Sails: Dec 23, More...

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