Rome Cruise Departures

Cruises that depart from Mediterranean: Italy: Rome

Cruises that visit Rome

See all River Cruises that depart from Rome

Click on a cruise ship itinerary sailing from Rome (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Rome), please visit: Cruise Search or try our Virtual Cruise Advisor™.

12 Night - Lake Como & Adriatic Romance Cruise Tour
Starting in Rome, Sorrento, Giardini Naxos, Kotor, Dubrovnik, Croatia, Split, Rovinj, Venice, Venice, Italy, Cernobbio
2027 Sails: Apr 12, Sep 23, More...

Viking Ocean, Viking Vesta

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2027 Sails: Apr 15, More...

Oceania Cruises, Oceania Allura

Deal link -> Special

7 Night - Viva Italia
Starting in Rome (Civitavecchia), Salerno, Messina (Sicily), Taranto, Bari, Kotor, Split, Trieste
2027 Sails: Apr 23, More...

Viking Ocean, Viking Sea

7 Night - Iconic Western Mediterranean
Starting in Rome (Civitavecchia), Florence / Pisa (Livorno), Monte Carlo, Marseille, Sete, Barcelona
2027 Sails: Apr 23, More...

Windstar Tours, Star Explorer Tours

10 Night - Vatican & Italian Riviera Cruise Tour
Starting in Rome, Portoferraio, Portofino, Monte Carlo, Cannes, Sanary-sur-mer, Palamos, Barcelona
2027 Sails: Apr 26, More...

Windstar, Wind Surf

7 Night - Enchanting Greece & the Amalfi Coast
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece
2027 Sails: Apr 27, More...

Windstar Tours, Wind Surf Tours

11 Night - Enchanting Meteora, Greece, and Amalfi Coast Cruise Tour
Starting in Rome, Sorrento, Messina (Taormina), Gythion, Monemvasia, Athens, Greece, Delphi, Athens, Greece
2027 Sails: Apr 27, More...

Windstar, Star Explorer

7 Night - Yachtsman's Harbors of the Rivieras
Starting in Rome, Portoferraio, Portofino, Monte Carlo, Cannes, Sanary-sur-mer, Palamos, Barcelona
2027 Sails: Apr 28, More...

Viking Ocean, Viking Neptune

21 Night - Adriatic & Mediterranean Sojourn
Starting in Rome (Civitavecchia), Naples, Sicily (Messina), Crotone, Bari, Sibenik, Venice, Split, Dubrovnik, Croatia, Kotor, Corfu (Kerkyra), Katakolon (Olympia), Athens (Piraeus), Crete (Heraklion), Rhodes, Ephesus (Kusadasi), Troy (Canakkale), Istanbul
2027 Sails: Apr 30, Jul 10, More...

Celebrity Cruises, Celebrity Ascent

11 Night - Greece, Italy & Malta Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Chania (Souda), Crete, Greece, Mykonos, Greece, Ephesus (Kusadasi), Turkey, Santorini, Greece, Athens (Piraeus), Greece, Valletta, Malta, Rome (Civitavecchia), Italy
2027 Sails: May 3, Sep 6, More...

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