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Puerto Rico Cruise Departures

Cruises that depart from Caribbean: Puerto Rico

Cruises that visit Puerto Rico

Click on a cruise ship itinerary sailing from Puerto Rico (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Puerto Rico), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: San Juan

Departing from
Puerto Rico
Cruise Specials

Princess Cruises, Grand Princess
Grand Princess18 Night - Southern Caribbean Adventurer
Starting in San Juan, Puerto Rico, St Maarten, Dominica, Grenada, Barbados, Tortola, British Virgin Islands, San Juan, Puerto Rico, St Thomas, US Virgin Islands, St Kitts, Aruba, Curacao, Bonaire, Caribbean Netherlands, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Fort Lauderdale, Florida
2026 Sails: Mar 29, More...
SeaDream Yacht Club, SeaDream II
SeaDream II7 Night - Turks & Caicos Cruise
Starting in San Juan, Samana, Grand Turk, Sailing the Bahamas Archipelago, Gordons Beach, Long Island, Staniel Cay, Exumas, Taino Beach, Grand Bahama, Palm Beach
2026 Sails: Mar 29, More...
Explora Journeys, EXPLORA II
EXPLORA II7 Night - A Journey from San Juan to Miami
Starting in San Juan, St Johns AG, Antigua, Gustavia, Puerto Plata, Dominican Republic, Key West, Miami
2026 Sails: Apr 2, More...
Explora Journeys, EXPLORA II
EXPLORA II23 Night - A Grand Journey from Caribbean Delights to Iberian Spectacle
Starting in San Juan, St Johns AG, Antigua, Gustavia, Puerto Plata, Dominican Republic, Key West, Miami, Kings Wharf, Horta, Ponta Delgada (Sao Miguel), Cadiz, Malaga, Spain, Barcelona
2026 Sails: Apr 2, More...
Ritz-Carlton, Evrima
Evrima4 Night - San Juan / San Juan
Starting in San Juan, St John VI, Gustavia, Virgin Gorda, San Juan
2026 Sails: Apr 4, More...
Princess Cruises, Grand Princess
Grand Princess27 Night - Panama Canal and Caribbean Adventurer
Starting in San Juan, Puerto Rico, St Thomas, US Virgin Islands, St Kitts, Aruba, Curacao, Bonaire, Caribbean Netherlands, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Fort Lauderdale, Florida, Aruba, Panama Canal Full Transit New Locks, Fuerte Amador, Panama (for Panama City), Puntarenas, Costa Rica, Puerto Chiapas, Mexico, Huatulco, Mexico, Puerto Vallarta, Mexico, Los Angeles, California
2026 Sails: Apr 5, More...
Princess Cruises, Grand Princess
Grand Princess11 Night - Southern Caribbean Islander
Starting in San Juan, Puerto Rico, St Thomas, US Virgin Islands, St Kitts, Aruba, Curacao, Bonaire, Caribbean Netherlands, Amber Cove, Dominican Republic, Grand Turk, Turks and Caicos, Fort Lauderdale, Florida
2026 Sails: Apr 5, More...
Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Southern Caribbean Cruise
Starting in San Juan, Puerto Rico, Charlotte Amalie, St Thomas, Tortola, Basseterre, St Kitts and Nevis, St Johns AG, Antigua, Castries, St Lucia, San Juan, Puerto Rico
2026 Sails: Apr 5, More...
Windstar, Star Seeker
Star Seeker7 Night - New World Caribbean Trio
Starting in San Juan, Isla Catalina, Santo Domingo, Cartagena CO, San Blas, Panama, Colon
2026 Sails: Apr 6, More...
Ritz-Carlton, Evrima
Evrima3 Night - San Juan / San Juan
Starting in San Juan, Gustavia, Virgin Gorda, San Juan
2026 Sails: Apr 8, More...

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Puerto Rico Cruise Departures