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Mediterranean Cruise Departures

Cruises that depart from Mediterranean

Cruises that visit Mediterranean

See all River Cruises that depart from Mediterranean

Click on a cruise ship itinerary sailing from Mediterranean (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mediterranean), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Croatia / Hrvatska : Cyprus : Egypt : Greece : Italy : Malta : Monaco : Slovenia : Turkey

Departing from
Mediterranean
Cruise Specials

EXPLORA II14 Night - An Extended Journey of Island Rhythms & Adriatic Echoes
Starting in Piraeus (Athens), Brindisi, Nydri, Lefkada, Pylos, Katapola, Mykonos, Piraeus (Athens), Paros, Patmos, Corfu, Hvar, Rijeka, Fusina (Venice)
2026 Sails: Jul 6, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jul 6, Aug 3, More...
MSC Cruises, MSC Seaview
MSC Seaview7 Night - Mediterranean
Starting in Palermo (Monreale), Italy, Ibiza (Balearic Islands), Spain, Barcelona, Spain, Marseille (Provence), France, Genoa (Portofino), Italy, Civitavecchia (Rome), Italy, Palermo (Monreale), Italy
2026 Sails: Jul 6, Jul 13, Jul 20, Jul 27, Aug 3, Aug 10, Aug 17, Aug 24, Aug 31, Sep 7, Sep 14, Sep 21, Sep 28, Oct 5, Oct 12, Oct 19, Oct 26, Nov 2, More...
Regent Seven Seas, Seven Seas Splendor
Seven Seas Splendor7 Night - Iconic Cote D'azur
Starting in Monte Carlo, Tuscany (Livorno), Cruising the Tyrrhenian Sea, Cagliari (Sardinia), La Goulette, Trapani (Sicily), Sorrento / Capri, Rome (Civitavecchia)
2026 Sails: Jul 6, More...
Royal Caribbean, Brilliance of the Seas
Brilliance of the Seas7 Night - Greek Isles & Italy Cruise
Starting in Rome (Civitavecchia), Italy, Naples, Italy, Sicily (Messina), Italy, Santorini, Greece, Ephesus (Kusadasi), Turkey, Mykonos, Greece, Athens (Piraeus), Greece
2026 Sails: Jul 6, Sep 28, More...
Celestyal Cruises, Celestyal Discovery
Celestyal Discovery4 Night - Iconic Greek Islands
Starting in Kusadasi, Patmos, Rhodes, Heraklion, Santorini, Lavrion, Athens, Mykonos, Kusadasi
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, 2027: Apr 6, Apr 13, Apr 20, Apr 27, May 4, May 11, May 18, May 25, Jun 1, More...
Costa Cruise Lines, Costa Toscana
Costa Toscana4 Night - Mediterranean from Cagliari to Marseille
Starting in Cagliari, Italy, Naples, Italy, Capri bay, Civitavecchia / Rome, Genoa / Portofino, Calanques national park bay, Marseilles, France
2026 Sails: Jul 7, More...
MSC Cruises, MSC Musica
MSC Musica7 Night - Mediterranean
Starting in Genoa (Portofino), Italy, Marseille (Provence), France, Valencia, Spain, Ibiza (Balearic Islands), Spain, Cagliari (Sardinia), Italy, Civitavecchia (Rome), Italy, Genoa (Portofino), Italy
2026 Sails: Jul 7, Aug 4, More...
MSC Cruises, MSC Orchestra
MSC Orchestra7 Night - Mediterranean
Starting in Civitavecchia (Rome), Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Tarragona, Spain, Valencia, Spain, Livorno (Florence), Italy, Civitavecchia (Rome), Italy
2026 Sails: Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, Oct 20, More...

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Mediterranean Cruise Departures