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Massachusetts Cruise Departures

Cruises that depart from North America: United States: Massachusetts

Cruises that visit Massachusetts

See all River Cruises that depart from Massachusetts

Click on a cruise ship itinerary sailing from Massachusetts (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Massachusetts), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Boston

Departing from
Massachusetts
Cruise Specials

American Cruise Lines, American Legend
American Legend Cruises7 Night - Yankee Seaports Cruise
Starting in Boston, Ma, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Sep 25, 2027: Jun 6, 2028: Jun 17, Jul 22, More...
American Cruise Lines, American Glory
American Glory Cruises7 Night - Yankee Seaports Cruise
Starting in Boston, Ma, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Sep 28, 2027: May 29, 2028: May 22, Jun 5, More...
Regent Seven Seas Cruises, Seven Seas Splendor
Seven Seas Splendor Cruises11 Night - Magnifique L'automne
Starting in Boston, Portland ME, Saint John NB (Bay of Fundy), Halifax, Sydney CA, Charlottetown, Cruising the Gulf of St Lawrence, Gaspesie, Sept-Iles, Saguenay, Quebec City, Montreal
2026 Sails: Sep 28, More...
PONANT, Le Bellot
Le Bellot Cruises13 Night - Nova Scotia and the East Coast of the United States
Starting in Boston, Halifax, Louisbourg, Lunenburg, Yarmouth, Nova Scotia, Eastport, Portland-OR, Province Town, Crossing the Cape Cod Canal, Newport, New York, Oak Bluffs, Marthas Vineyard, Boston
2026 Sails: Oct 6, More...
American Cruise Lines, American Maverick
American Maverick Cruises7 Night - Yankee Seaports Cruise
Starting in Boston, Ma, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Oct 9, 2027: Oct 26, More...
Crystal, Crystal Symphony
Crystal Symphony Cruise Ship7 Night - North America & Canada
Starting in Boston, Yarmouth, Halifax, Sydney NS, Nova Scotia, Charlottetown, Prince Edward Island, Quebec City, Montreal
2026 Sails: Oct 9, More...
Princess Cruise Tours, Sapphire Princess Cruise Tours
Sapphire Princess Cruise Tours15 Night - Maple Explorer - Tour 2D
Starting in Boston, Massachusetts, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney CA, Charlottetown, Canada, Saguenay, Canada, Quebec City, Canada, Montebello, Canada, Montreal, Canada, Ottawa, Canada, Toronto, Canada
2026 Sails: Oct 13, More...
Princess Cruises, Sapphire Princess
Sapphire Princess Cruise Ship10 Night - Classic Canada & New England
Starting in Boston, Massachusetts, Saint John NB (Bay of Fundy), Halifax, Canada, Sydney CA, Charlottetown, Canada, Saguenay, Canada, Quebec City, Canada
2026 Sails: Oct 13, More...
American Cruise Lines, American Pioneer
American Pioneer Cruises7 Night - Yankee Seaports Cruise
Starting in Boston, Ma, Plymouth, MA, Newport, Ri, New London / Mystic, CT, Sag Harbor, NY, Old Saybrook, CT, New York, NY
2026 Sails: Oct 18, 2027: Oct 23, More...
Celebrity Cruises, Celebrity Silhouette
Celebrity Silhouette Cruise Ship10 Night - Boston to Fort Lauderdale
Starting in Boston, Massachusetts, Willemstad AN, Curacao, Kralendijk, Bonaire, Oranjestad, Aruba, Fort Lauderdale, Florida
2026 Sails: Oct 20, More...

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Massachusetts Cruise Departures