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Knoxville Cruise Departures

Cruises that depart from North America: United States: Tennessee: Knoxville

Click on a cruise ship itinerary sailing from Knoxville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Knoxville), please visit: Cruise Search or try our Virtual Cruise Advisor™.


American Cruise Lines Cruise Tours, American Symphony Cruise Tours
American Symphony Cruise Tours11 Night - Great Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: May 2, May 16, May 30, Jun 13, Sep 19, Oct 3, Oct 17, 2027: May 1, May 15, May 29, Jun 12, Oct 5, Oct 19, More...
American Cruise Lines Cruise Tours, American Splendor Cruise Tours
American Splendor Cruise Tours11 Night - Great Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

Knoxville Cruise Departures