Knoxville Cruise Departures

Cruises that depart from North America: United States: Tennessee: Knoxville

Cruises that visit Knoxville

See all River Cruises that depart from Knoxville

Click on a cruise ship itinerary sailing from Knoxville (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Knoxville), please visit: Cruise Search or try our Virtual Cruise Advisor™.

American Lines Tours, American Symphony Tours

11 Night - Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: May 2, May 16, May 30, Jun 13, Sep 19, Oct 3, Oct 17, More...

American Lines Tours, American Splendor Tours

11 Night - Smoky Mountains National Park
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountain National Park, Chattanooga, TN, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: Aug 15, Aug 29, Sep 12, Sep 26, Oct 10, More...

American Lines Tours, American Heritage Tours

10 Night - Great Smoky Mountains Cruise
Starting in Knoxville, TN, Pigeon Forge, TN, Great Smoky Mountains National Park, Cruising Along the Great Smoky Mountains to Knoxville, TN, Fort Southwest Point, TN, Cruising Along the Appalachian Mountains, Chattanooga, TN, Cruising the Tennessee River, Decatur, AL, Huntsville, AL
2027 Sails: Jul 13, Jul 25, Aug 6, Aug 18, Aug 30, Sep 11, Sep 23, Oct 5, Oct 17, 2028: Jul 12, Jul 24, Aug 5, Aug 17, Aug 29, Sep 10, Sep 22, Oct 4, Oct 16, More...

Knoxville Cruise Departures