Florida Cruise Departures

Cruises that depart from North America: United States: Florida

Cruises that visit Florida

See all River Cruises that depart from Florida

Click on a cruise ship itinerary sailing from Florida (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Florida), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Royal Caribbean, Explorer of the Seas

9 Night - Southern Caribbean Cruise
Starting in Orlando (Port Canaveral), Fl, St Johns AG, Antigua, Bridgetown, Barbados, Roseau, Dominica, Basseterre, St Kitts and Nevis, Orlando (Port Canaveral), Fl
2026 Sails: Nov 18, More...

Silversea, Silver Shadow

12 Night - Miami to Miami
Starting in Miami, Fl, San Juan, St John VI, Gustavia, St Barthelemy, St Johns, Little Bay, Montserrat, St Kitts (Basseterre), Jost Van Dyke, British Virgin Islands, Miami, Fl
2026 Sails: Nov 18, More...

MSC Cruises, MSC Seashore

10 Night - Caribbean and Antilles
Starting in Port Canaveral (Orlando), Florida, Nassau, Bahamas, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando), Florida, Nassau, Bahamas, Ocho Rios, Jamaica, George Town, Cayman Islands, Ocean Cay Msc Marine Reserve, Bahamas, Port Canaveral (Orlando), Florida
2026 Sails: Nov 19, Dec 17, More...

Princess Cruises, Majestic Princess

Deal link -> Special

18 Night - Brazilian Adventure
Starting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina
2026 Sails: Nov 19, More...

Princess Cruises, Majestic Princess

33 Night - Brazilian & Cape Horn Grand Adventure
Starting in Fort Lauderdale, Florida, St Maarten, St Lucia, Barbados, Fortaleza, Brazil, Rio De Janeiro, Brazil, Montevideo, Uruguay, Buenos Aires, Argentina, Montevideo, Uruguay, Puerto Madryn, Argentina, Port Stanley, Falkland Islands, Cape Horn (Scenic Cruising), Ushuaia (Tierra del Fuego), Argentina, Beagle Channel Fjords and Glacier Alley, Chile, Punta Arenas, Chile, Puerto Montt, Chile, San Antonio CL (for Santiago), Chile
2026 Sails: Nov 19, More...

Royal Caribbean, Freedom of the Seas

9 Night - Southern Caribbean & Perfect Day
Starting in Miami, Florida, Willemstad AN, Curacao, Oranjestad, Aruba, Perfect Day Cococay, Bahamas, Miami, Florida
2026 Sails: Nov 19, More...

Virgin Voyages, Scarlet Lady

4 Night - Key West & Bimini Beach Club
Starting in Miami, Key West, The Beach Club at Bimini, Bahamas, Miami
2026 Sails: Nov 19, Dec 3, Dec 17, 2027: Jan 14, Jan 28, Feb 11, Feb 25, Mar 11, Mar 25, Apr 8, More...

Holland America, Nieuw Amsterdam

9 Night - Southern Caribbean
Starting in Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida
2026 Sails: Nov 20, More...

Holland America, Nieuw Amsterdam

21 Night - Southern & Eastern Caribbean Discovery
Starting in Fort Lauderdale, Florida, Kralendijk, Bonaire, Willemstad AN, Curacao, RelaxAway, Half Moon Cay, Bahamas, Fort Lauderdale, Florida, Philipsburg, Sint Maarten, Fort-De-France, Martinique, Bridgetown, Barbados, Scarborough, Trinidad and Tobago, Castries, Saint Lucia, Basseterre, St Kitts and Nevis, Key West, Florida, Fort Lauderdale, Florida
2026 Sails: Nov 20, More...

Margaritaville at Sea, Margaritaville Islander

5 Night - Mexico Duo
Starting in Port Tampa Bay, Cozumel, Mexico, Progreso, Mexico, Port Tampa Bay
2026 Sails: Nov 20, 2027: Jan 16, Mar 13, Mar 18, Mar 27, Apr 10, Apr 24, May 3, May 17, May 31, Jun 28, Jul 12, Sep 27, Nov 18, Dec 2, 2028: Apr 24, More...

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