Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail:
Aare River : Amstel River : Cibin River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Plitvice Lakes : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River

14 Night - Splendours of Europe
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest
2026 Sails: Jun 19, Jul 17, Oct 11, More...

Emerald Cruises, Emerald Sky

17 Night - Splendours of Europe & Prague
Starting in Amsterdam, Cologne, Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau, Melk / Durnstein, Vienna, Bratislava, Budapest, Budapest / Prague, Prague
2026 Sails: Jun 19, Jul 17, More...

Viking River, Viking Idi

7 Night - Castles, Vineyards & Villages
Starting in Amsterdam, Kinderdijk, Cologne, Koblenz, Middle Rhine Scenic Sailing, Scenic Sailing Main River, Wertheim, Wurzburg, Bamberg, Nuremberg, Bamberg
2026 Sails: Jun 19, More...

Uniworld, River Duchess

14 Night - European Jewels
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest
2026 Sails: Jun 21, Aug 2, Sep 13, Oct 11, More...

Uniworld Tours, River Duchess Tours

23 Night - Ultimate European Journey
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest, Batina (Osijek), Vukovar, Belgrade, Golubac, Cruising the Iron Gates, Vidin, Ruse, Giurgiu, Transfer to Bucharest, Bucharest
2026 Sails: Jun 21, Aug 2, More...

Amadeus River, MS Amadeus Aurea

7 Night - Rhine & Danube Symphony
Starting in Cologne, Rudesheim, Miltenberg, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau
2026 Sails: Jun 23, More...

Avalon Waterways, Avalon Impression

14 Night - Magnificent Europe
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Cologne, Germany, Rhine Gorge / Rudesheim, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Regensburg, Passau, Melk / Wachau Valley, Vienna, Budapest, Hungary, Budapest (Disembarkation)
2026 Sails: Jun 23, Aug 18, Oct 13, More...

Scenic Luxury, Scenic Jasper

14 Night - Jewels of Europe
Starting in Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Jun 23, More...

Scenic Luxury, Scenic Jasper

17 Night - Jewels of Europe with Paris
Starting in Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam, Amsterdam / Paris, Paris
2026 Sails: Jun 23, More...

Scenic Luxury, Scenic Opal

14 Night - Jewels of Europe
Starting in Amsterdam, Cologne / Bonn, Rhine Gorge / Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau / Schlogen, Durnstein / Krems, Vienna, Budapest
2026 Sails: Jun 23, Aug 4, More...

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