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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail: Aare River : Amstel River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


AmaWaterways Cruise Tours, AmaCerto Cruise Tours
AmaCerto Cruise Tours14 Night - Medieval Treasures with Zurich, Lake Lucerne Pre-Cruise and Prague Post-Cruise
Starting in Zurich, Lucerne, Basel, Strasbourg, Ludwigshafen, Frankfurt, Miltenberg, Wertheim, Wurzburg, Nuremberg, Pilzen, Prague
2027 Sails: May 1, Jul 10, Aug 21, Oct 2, More...
Uniworld Boutique River Cruise Tours, S.S. Audrey Cruise Tours
S.S. Audrey Cruise Tours11 Night - Paris, Prague & Germany's Hidden Gems
Starting in Paris, Paris, Trier, Trier, Luxembourg, Cochem, Rudesheim, Aschaffenburg (Heidelberg), Wertheim, Kitzingen, Volkach, Bamberg, Prague, Prague, Depart Prague
2027 Sails: May 1, Jun 18, Jul 16, More...
Avalon Waterways, Avalon Imagery II
Avalon Imagery II Cruises9 Night - Reflections On the Rhine (Southbound)
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Nijmegen, Cologne, Germany, Rhine Gorge / Rudesheim, Frankfurt, Ludwigshafen Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation)
2027 Sails: May 2, More...
Avalon Waterways Cruise Tours, Avalon Imagery II Cruise Tours
Avalon Imagery II Cruises11 Night - Reflections On the Rhine with in Lucerne (Southbound)
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Nijmegen, Cologne, Germany, Rhine Gorge / Rudesheim, Frankfurt, Ludwigshafen Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation) Swiss Alps, Lucerne
2027 Sails: May 2, More...
Riviera River Cruises, MS Riviera Radiance
MS Riviera Radiance Cruises14 Night - Cruise the Heart of Europe
Starting in Budapest, Hungary, Bratislava, Slovakia, Vienna, Austria, Melk, Austria, Passau, Germany, Main-Danube Canal, Nuremberg, Germany, Main River, Wurzburg, Miltenberg, Germany, Rudesheim, Germany, Boppard, Germany, Koblenz, Germany, Cologne, Germany
2027 Sails: May 2, More...
Uniworld Boutique River Cruise Collection, S.S. Emilie
S.S. Emilie Cruises14 Night - European Gems
Starting in Amsterdam, Dusseldorf, Rudesheim, Mainz, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Roth, Regensburg, Passau, Engelhartszell, Durnstein, Vienna
2027 Sails: May 2, More...
Uniworld Boutique River Cruise Collection, S.S. Marlene
S.S. Marlene Cruises14 Night - European Jewels
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest
2027 Sails: May 2, Jun 13, Sep 19, More...
Uniworld Boutique River Cruise Tours, S.S. Marlene Cruise Tours
S.S. Marlene Cruise Tours23 Night - Ultimate European Journey
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest, Batina (Osijek), Vukovar, Belgrade, Golubac, Cruising the Iron Gates, Vidin, Ruse, Giurgiu, Transfer to Bucharest, Bucharest
2027 Sails: May 2, Jun 13, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises20 Night - Prague to Paris & Splendours of Europe
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam, Amsterdam / Paris, Paris
2027 Sails: May 4, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises17 Night - Prague & Splendours of Europe
Starting in Prague, Prague / Budapest, Budapest, Bratislava, Vienna, Durnstein / Melk, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Koblenz, Cologne, Amsterdam
2027 Sails: May 4, More...

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Main River Cruises