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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail:
Aare River : Amstel River : Cibin River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


Avalon Waterways, Avalon Imagery II
Avalon Imagery II Cruises9 Night - Reflections On the Rhine (Southbound)
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Nijmegen, Cologne, Germany, Rhine Gorge / Rudesheim, Frankfurt, Ludwigshafen Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation)
2027 Sails: May 2, More...
Avalon Waterways Cruise Tours, Avalon Imagery II Cruise Tours
Avalon Imagery II Cruises11 Night - Reflections On the Rhine with in Lucerne (Southbound)
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Nijmegen, Cologne, Germany, Rhine Gorge / Rudesheim, Frankfurt, Ludwigshafen Excursion to Heidelberg, Strasbourg, France, Breisach, Germany Excursion to Black Forest, Basel, Switzerland (Disembarkation) Swiss Alps, Lucerne
2027 Sails: May 2, More...
Riviera River Cruises, MS Riviera Radiance
MS Riviera Radiance Cruises14 Night - Cruise the Heart of Europe
Starting in Budapest, Hungary, Bratislava, Slovakia, Vienna, Austria, Melk, Austria, Passau, Germany, Main-Danube Canal, Nuremberg, Germany, Main River, Wurzburg, Miltenberg, Germany, Rudesheim, Germany, Boppard, Germany, Koblenz, Germany, Cologne, Germany
2027 Sails: May 2, More...
Scenic Luxury Cruises, Scenic Ruby
Scenic Ruby Cruises10 Night - Castles & Vineyards of the Rhine & Moselle with Berlin
Starting in Berlin, Berlin / Frankfurt, Koblenz, Bernkastel, Cochem, Rudesheim, Rastatt, Breisach, Basel / Zurich
2027 Sails: May 2, Jul 18, More...
Scenic Luxury Cruises, Scenic Ruby
Scenic Ruby Cruises14 Night - Castles & Vineyards of the Rhine & Moselle with Berlin
Starting in Berlin, Berlin / Frankfurt, Koblenz, Bernkastel, Cochem, Rudesheim, Rastatt, Breisach, Basel / Montreux, Montreux, Montreux / Bern, Bern / Lucerne / Zurich, Zurich
2027 Sails: May 2, Jul 18, More...
Scenic Luxury Cruises, Scenic Ruby
Scenic Ruby Cruises10 Night - Castles & Vineyards of the Rhine & Moselle with Berlin
Starting in Berlin, Berlin / Frankfurt, Koblenz, Bernkastel, Cochem, Rudesheim, Rastatt, Breisach, Basel
2027 Sails: May 2, Jul 18, More...
Uniworld Boutique River Cruise Collection, S.S. Emilie
S.S. Emilie Cruises14 Night - European Gems
Starting in Amsterdam, Dusseldorf, Rudesheim, Mainz, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Roth, Regensburg, Passau, Engelhartszell, Durnstein, Vienna
2027 Sails: May 2, More...
Uniworld Boutique River Cruise Collection, S.S. Marlene
S.S. Marlene Cruises14 Night - European Jewels
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest
2027 Sails: May 2, Jun 13, Sep 19, More...
Uniworld Boutique River Cruise Tours, S.S. Marlene Cruise Tours
S.S. Marlene Cruise Tours23 Night - Ultimate European Journey
Starting in Amsterdam, Cologne, Rudesheim, Frankfurt (Heidelberg), Wertheim, Wurzburg, Cruising the Main River, Kitzingen (Rothenburg), Bamberg, Nuremberg, Cruising the Main-Danube Canal, Regensburg, Passau, Weissenkirchen (Melk), Tulln, Vienna, Budapest, Batina (Osijek), Vukovar, Belgrade, Golubac, Cruising the Iron Gates, Vidin, Ruse, Giurgiu, Transfer to Bucharest, Bucharest
2027 Sails: May 2, Jun 13, More...
Riviera River Cruises, MS Emily Bronte
MS Emily Bronte Cruises10 Night - Rhine Cruise to Switzerland (Including Glacier Express Extension)
Starting in Cologne, Germany, Rhine River, Koblenz, Germany, Rudesheim, Germany, Speyer, Germany, Rhine River, Basel, Switzerland, Davos, Switzerland, Zermatt, Switzerland
2027 Sails: May 3, May 17, Jul 19, Aug 9, Aug 30, Sep 20, More...

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Main River Cruises