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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail:
Aare River : Amstel River : Cibin River : Corrib River : Dambovita River : Danube River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


Avalon Waterways, Avalon Expression
Avalon Expression Cruises21 Night - Iconic Rivers of Europe - the Rhine, Main & Danube
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Cologne, Germany, Rhine Gorge / Rudesheim, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Regensburg, Passau, Melk / Wachau Valley, Vienna, Budapest, Hungary, Budapest, Vukovar, Novi Sad, Serbia, Belgrade, Golubac / Donji Milanovac Excursion to Lepenski Vir / Iron Gates Gorge, Vidin, Bulgaria, Rousse / Veliko Tarnovo and Arbanassi Excursion, Oltenita, Romania (Disembarkation)
2026 Sails: Jul 9, More...
Avalon Waterways Cruise Tours, Avalon Expression Cruise Tours
Avalon Expression Cruises24 Night - Iconic Rivers of Europe - the Rhine, Main & Danube with in Bucharest and in Transylvania
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Cologne, Germany, Rhine Gorge / Rudesheim, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Regensburg, Passau, Melk / Wachau Valley, Vienna, Budapest, Hungary, Budapest, Vukovar, Novi Sad, Serbia, Belgrade, Golubac / Donji Milanovac Excursion to Lepenski Vir / Iron Gates Gorge, Vidin, Bulgaria, Rousse / Veliko Tarnovo and Arbanassi Excursion, Oltenita, Romania (Disembarkation) Bucharest, Brasov, Brasov / Sinaia / Bucharest, Bucharest
2026 Sails: Jul 9, More...
Avalon Waterways Cruise Tours, Avalon Expression Cruise Tours
Avalon Expression Cruises22 Night - Iconic Rivers of Europe - the Rhine, Main & Danube with in Bucharest
Starting in Amsterdam, Holland (Embarkation), Amsterdam, Cologne, Germany, Rhine Gorge / Rudesheim, Miltenberg, Wurzburg, Volkach, Bamberg, Nuremberg, Regensburg, Passau, Melk / Wachau Valley, Vienna, Budapest, Hungary, Budapest, Vukovar, Novi Sad, Serbia, Belgrade, Golubac / Donji Milanovac Excursion to Lepenski Vir / Iron Gates Gorge, Vidin, Bulgaria, Rousse / Veliko Tarnovo and Arbanassi Excursion, Oltenita, Romania (Disembarkation) Bucharest, Bucharest
2026 Sails: Jul 9, More...
Scenic Luxury Cruises, Scenic Jade
Scenic Jade Cruises33 Night - Jewels of Europe with Majestic Britain & Ireland
Starting in Dublin, Dublin / Killarney, Killarney, Killarney / Galway, Galway / Belfast, Belfast, Belfast / Loch Lomond, Loch Lomond, Loch Lomond / Inverness, Inverness, Inverness / Edinburgh, Edinburgh, Edinburgh / York, York, York / Bath, Bath, Bath / London, London, London / Amsterdam, Amsterdam, Cologne / Bonn, Rhine Gorge / Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau / Schlogen, Durnstein / Krems, Vienna, Budapest
2026 Sails: Jul 10, Sep 4, More...
Uniworld Boutique River Cruise Tours, River Duchess Cruise Tours
River Duchess Cruise Ship23 Night - Ultimate European Journey
Starting in Bucharest, Bucharest, Transfer to Giurgiu, Ruse, Vidin, Cruising the Iron Gates, Donji Milanovac, Golubac, Belgrade, Ilok, Aljmas, Budapest, Cruising the Danube River, Vienna, Vienna, Cruising the Wachau Valley, Weissenkirchen (Melk), Passau, Regensburg, Nuremberg, Bamberg, Wurzburg (Rothenburg), Wertheim, Frankfurt (Heidelberg), Rudesheim, Cologne, Amsterdam
2026 Sails: Jul 10, Aug 21, More...
Emerald Cruises, Emerald Dawn
Emerald Dawn Cruises10 Night - Jewels of the Rhine & Glacier Express
Starting in Amsterdam, Dusseldorf / Cologne, Koblenz, Mannheim (Heidelberg), Kehl / Strasbourg, Breisach / Freiburg, Basel / Zermatt, Zermatt, Zermatt / Zurich, Zurich
2026 Sails: Jul 11, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises7 Night - The Majestic Rhine
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Zurich
2026 Sails: Jul 11, 2027: Aug 16, Sep 6, More...
Emerald Cruises, Emerald Sun
Emerald Sun Cruises7 Night - The Majestic Rhine
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel
2026 Sails: Jul 11, 2027: Aug 16, Sep 6, More...
Riviera River Cruises, MS William Wordsworth
MS William Wordsworth Cruises14 Night - Cruise the Heart of Europe
Starting in Cologne, Germany, Koblenz, Germany, Boppard, Germany, Rudesheim, Germany, Miltenberg, Germany, Wurzburg, Main River, Nuremberg, Germany, Main-Danube Canal, Passau, Germany, Melk, Austria, Vienna, Austria, Bratislava, Slovakia, Budapest, Hungary
2026 Sails: Jul 13, More...
Amadeus River Cruises, MS Amadeus Aurea
MS Amadeus Aurea Cruises14 Night - Across Europe - Budapest to Amsterdam
Starting in Budapest, Bratislava, Vienna, Durnstein, Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim, Rudesheim, Cologne, Utrecht, Amsterdam
2026 Sails: Jul 14, More...

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Main River Cruises