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Lyon Cruise Departures

Cruises that depart from Europe: France: Lyon

Cruises that visit Lyon

See all River Cruises that depart from Lyon

Click on a cruise ship itinerary sailing from Lyon (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Lyon), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Uniworld, S.S. Catherine
S.S. Catherine7 Night - Burgundy & Provence
Starting in Lyon, Macon (Beaune), Tain-lHermitage (Tournon), Viviers, Avignon, Arles
2026 Sails: Aug 16, Aug 30, Sep 13, Sep 27, Oct 11, Oct 25, More...
Scenic Luxury, Scenic Sapphire
Scenic Sapphire7 Night - Idyllic Rhone
Starting in Lyon, Macon, Vienne, Viviers / Avignon, Avignon, Arles, Tarascon / Marseille
2026 Sails: Aug 22, More...
Scenic Luxury, Scenic Sapphire
Scenic Sapphire7 Night - Idyllic Rhone
Starting in Lyon, Macon, Vienne, Viviers / Avignon, Avignon, Arles, Tarascon / Nice
2026 Sails: Aug 22, 2027: Apr 26, More...
Riviera River, MS Thomas Hardy
MS Thomas Hardy10 Night - Lyon, Provencal Rhone & the Camargue River Cruise
Starting in Lyon, France, Macon, France, Chalon, France, Lyon, France, Le Pouzin, France, Avignon, France, Arles, France, Chateauneuf-du-Pape, France, Rhone River, Lyon, France
2026 Sails: Aug 26, Sep 19, Oct 13, 2027: Apr 11, May 5, Jun 12, Jul 20, Sep 24, Oct 18, More...
AmaWaterways, AmaKristina
AmaKristina7 Night - Colors of Provence
Starting in Lyon, Vienne, Tournon, Viviers, Avignon, Arles
2026 Sails: Aug 27, Sep 24, Oct 22, Dec 3, Dec 17, 2027: May 6, Aug 12, Oct 7, Oct 21, Dec 2, 2028: Apr 6, May 18, Jun 15, Jun 29, Sep 7, Oct 5, Oct 19, More...
Avalon Waterways, Avalon Poetry II
Avalon Poetry II7 Night - Active & Discovery On the Rhone (Southbound)
Starting in Lyon, France (Embarkation), Lyon, Tain-LHermitage / Tournon, Viviers / Lock Bollene, Avignon, Arles, Port-saint-louis, Arles (Disembarkation)
2026 Sails: Sep 22, More...
AmaWaterways, AmaKristina
AmaKristina7 Night - Colors of Provence (Smithsonian Journeys)
Starting in Lyon, Vienne, Tournon, Avignon, Arles
2026 Sails: Oct 8, More...
Emerald Cruises, Emerald Liberte
Emerald Liberte7 Night - Autumn Sensations of Lyon & Provence
Starting in Lyon, Vienne, Tournon, Viviers, Avignon, Arles, Arles / Marseille
2026 Sails: Oct 10, Oct 24, Nov 21, 2027: Apr 10, Oct 9, Nov 20, Dec 4, More...
Emerald Cruises, Emerald Liberte
Emerald Liberte7 Night - Autumn Sensations of Lyon & Provence
Starting in Lyon, Vienne, Tournon, Viviers, Avignon, Arles, Arles / Nice
2026 Sails: Oct 10, Oct 24, Nov 21, 2027: Apr 10, Oct 9, More...
Riviera River, MS Lord Byron
MS Lord Byron7 Night - Burgundy, the River Rhone & Provence River Cruise
Starting in Lyon, France, Chalon, France, Vienne, France, Tain IHermitage, France, Arles, France, Avignon, France
2026 Sails: Oct 19, 2027: Apr 1, Apr 15, May 9, Jun 2, Jun 16, Jul 10, Jul 24, Aug 17, Aug 31, Sep 14, Oct 8, Oct 22, More...

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Lyon Cruise Departures