Ho Chi Minh City Cruise Departures
Cruises that depart from Asia/Far East: Vietnam: Ho Chi Minh City
Cruises that visit Ho Chi Minh City
See all River Cruises that depart from Ho Chi Minh City
9 Night - Charms of the Mekong with Ho Chi Minh City Pre-Cruise
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, More...11 Night - Charms of the Mekong with Ho Chi Minh City Pre-Cruise and Siem Reap Post-Cruise
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, More...15 Night - Charms of the Mekong with Ho Chi Minh City Pre-Cruise and Siem Reap, Hanoi, Ha Long Bay, Hanoi Post-Cruise
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap, Hanoi
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Mar 6, Mar 20, Apr 3, Apr 17, More...7 Night - Charms of the Mekong
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 6, Apr 20, Aug 10, Aug 24, Sep 7, Sep 21, Oct 5, Oct 19, Nov 2, Nov 30, Dec 14, Dec 28, 2027: Jan 11, Jan 25, Feb 8, Feb 22, Mar 8, Mar 22, Apr 5, Apr 19, Aug 9, Sep 6, Sep 20, Oct 4, More...9 Night - Charms of the Mekong with Siem Reap Post-Cruise
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 6, Apr 20, 2027: Jan 11, Jan 25, Feb 8, Mar 8, Mar 22, Apr 5, Apr 19, More...
12 Night - Wonders of Vietnam, Cambodia & the Mekong
Starting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: Apr 9, Apr 23, May 7, More...7 Night - Majestic Mekong Cruise
Starting in Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation to Phnom Penh
2026 Sails: Apr 11, Apr 25, May 9, More...
12 Night - Treasures of the Mekong
Starting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Cai Be / Sa Dec, Tan Chau / Border Crossing, Phnom Penh, Phnom Penh / Oudong, Silk Island / Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: May 17, Sep 27, Oct 11, Oct 25, Nov 8, 2027: Jan 10, Jan 24, Mar 21, Apr 4, Apr 18, May 2, May 16, Sep 26, Oct 10, Oct 24, Nov 7, Nov 21, Dec 26, More...10 Night - Luxury Mekong and Temple Discovery Cruise
Starting in Ho Chi Minh City / Mekong Cruise, Cai Be / Sa Dec, Tan Chau / Border Crossing, Phnom Penh, Phnom Penh / Oudong, Silk Island / Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: May 19, Sep 29, Oct 13, Oct 27, Nov 10, 2027: Jan 12, Jan 26, Mar 23, Apr 6, Apr 20, May 4, May 18, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 28, More...14 Night - Treasures of the Mekong Meandering Cruise
Starting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Cai Be, Sa Dec, Tan Chau, Border Crossing / Phnom Penh, Phnom Penh, Phnom Penh / Oudong / Silk Island, Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: Jul 19, Aug 6, Aug 24, Sep 11, Dec 6, Dec 24, 2027: Jul 18, Aug 5, Aug 23, Sep 10, Dec 7, More...
Cruises that depart from Asia/Far East: Vietnam: Ho Chi Minh City
Cruises that visit Ho Chi Minh City
See all River Cruises that depart from Ho Chi Minh City
Click on a cruise ship itinerary sailing from Ho Chi Minh City (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Ho Chi Minh City), please visit: Cruise Search or try our Virtual Cruise Advisor™.
9 Night - Charms of the Mekong with Ho Chi Minh City Pre-CruiseStarting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, More...
11 Night - Charms of the Mekong with Ho Chi Minh City Pre-Cruise and Siem Reap Post-CruiseStarting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Feb 20, Mar 6, Mar 20, Apr 3, Apr 17, More...
15 Night - Charms of the Mekong with Ho Chi Minh City Pre-Cruise and Siem Reap, Hanoi, Ha Long Bay, Hanoi Post-CruiseStarting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap, Hanoi
2026 Sails: Apr 4, 2027: Jan 9, Jan 23, Feb 6, Mar 6, Mar 20, Apr 3, Apr 17, More...
7 Night - Charms of the MekongStarting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 6, Apr 20, Aug 10, Aug 24, Sep 7, Sep 21, Oct 5, Oct 19, Nov 2, Nov 30, Dec 14, Dec 28, 2027: Jan 11, Jan 25, Feb 8, Feb 22, Mar 8, Mar 22, Apr 5, Apr 19, Aug 9, Sep 6, Sep 20, Oct 4, More...
9 Night - Charms of the Mekong with Siem Reap Post-CruiseStarting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Apr 6, Apr 20, 2027: Jan 11, Jan 25, Feb 8, Mar 8, Mar 22, Apr 5, Apr 19, More...
12 Night - Wonders of Vietnam, Cambodia & the MekongStarting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: Apr 9, Apr 23, May 7, More...
7 Night - Majestic Mekong CruiseStarting in Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation to Phnom Penh
2026 Sails: Apr 11, Apr 25, May 9, More...
12 Night - Treasures of the MekongStarting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Cai Be / Sa Dec, Tan Chau / Border Crossing, Phnom Penh, Phnom Penh / Oudong, Silk Island / Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: May 17, Sep 27, Oct 11, Oct 25, Nov 8, 2027: Jan 10, Jan 24, Mar 21, Apr 4, Apr 18, May 2, May 16, Sep 26, Oct 10, Oct 24, Nov 7, Nov 21, Dec 26, More...
10 Night - Luxury Mekong and Temple Discovery CruiseStarting in Ho Chi Minh City / Mekong Cruise, Cai Be / Sa Dec, Tan Chau / Border Crossing, Phnom Penh, Phnom Penh / Oudong, Silk Island / Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: May 19, Sep 29, Oct 13, Oct 27, Nov 10, 2027: Jan 12, Jan 26, Mar 23, Apr 6, Apr 20, May 4, May 18, Sep 28, Oct 12, Oct 26, Nov 9, Nov 23, Dec 28, More...
14 Night - Treasures of the Mekong Meandering CruiseStarting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Cai Be, Sa Dec, Tan Chau, Border Crossing / Phnom Penh, Phnom Penh, Phnom Penh / Oudong / Silk Island, Angkor Ban, Wat Hanchey / Kampong Cham, Mekong Cruise / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: Jul 19, Aug 6, Aug 24, Sep 11, Dec 6, Dec 24, 2027: Jul 18, Aug 5, Aug 23, Sep 10, Dec 7, More...
