Mekong River Cruises

River Cruises sailing on the Mekong River

Click on a cruise ship itinerary sailing on the Mekong River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Mekong River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Mekong River also sail:
Cambodia Waterways : Chao Phraya River : Japan Coast : Laos Waterways : Perfume River : Ping River : Red River : Saigon River : Thailand Waterways : Thu Bon River : Tonle Sap Lake : Tonle Sap River : Vietnam Waterways

7 Night - Charms of the Mekong
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Feb 23, Apr 6, Apr 20, Aug 10, Aug 24, Sep 7, Sep 21, Oct 5, Oct 19, Nov 2, Nov 30, Dec 14, Dec 28, 2027: Jan 11, Jan 25, Feb 8, Feb 22, Mar 8, Mar 22, Apr 5, Apr 19, Aug 9, Sep 6, Sep 20, More...

AmaWaterways Tours, AmaDara Tours

9 Night - Charms of the Mekong with Siem Reap Post-Cruise
Starting in Ho Chi Minh City, My Tho, Cai Be, Safford, Tan Chau, Phnom Penh, Atka, Port Clarence, Siem Reap
2026 Sails: Feb 23, Apr 6, Apr 20, 2027: Jan 11, Jan 25, Feb 8, Mar 8, Mar 22, Apr 5, Apr 19, More...

Viking River Tours, Viking Saigon Tours

14 Night - Magnificent Mekong
Starting in Ho Chi Minh City, Sa Dec, Tan Chau, Phnom Penh, Scenic Sailing : Mekong River, Kampong Cham, Siem Reap, Hanoi
2026 Sails: Feb 23, Aug 17, Aug 31, Sep 14, Oct 12, Oct 26, Nov 9, Nov 23, Dec 7, Dec 21, 2027: Jan 4, Jan 18, Feb 1, Feb 15, Mar 1, Mar 15, Mar 29, Aug 9, Aug 23, Sep 6, Sep 20, Oct 4, Oct 18, Nov 1, More...

Pandaw River, RV Indochina Pandaw

4 Night - Phnom Penh and Siem Reap
Starting in Phnom Penh, Tonle Sap River, Oudong Meditations and Pak Russei Silk, Peam Chi Korng Pottery Village, Siem Reap Disembarkation
2026 Sails: Feb 24, More...

Pandaw River, RV Mekong Pandaw

Pandaw River, RV Tonle Pandaw

4 Night - Saigon and Phnom Penh Short Cruise
Starting in Phnom Penh Embarkation, Into, Vietnam, Chau Doc and the Fertile Waterways, Ben Tre and Sailing Into Saigon, Saigon Disembarkation
2026 Sails: Feb 25, Mar 11, Mar 25, More...

Avalon Waterways, Avalon Saigon

7 Night - Mekong Discovery (Southbound)
Starting in Phnom Penh, Cambodia (Embarkation), Wat Hanchey / Angkor Ban, Kampong Tralach / Konpong Louang / Phnom Penh, Phnom Penh, Border Crossing / Chau Doc, Vietnam, Long Khanh / Cu Lao Gieng, Vinh Long, Ho Chi Minh City (Disembarkation)
2026 Sails: Feb 26, Mar 26, Apr 9, Apr 23, Aug 13, Aug 27, Sep 10, Sep 24, Nov 5, Nov 19, Dec 3, More...

Emerald Cruises, Emerald Harmony

15 Night - Wonders of Indochina and the Mekong
Starting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation / Siem Reap, Siem Reap, Siem Reap / Luang Prabang, Luang Prabang
2026 Sails: Feb 26, More...

Emerald Cruises, Emerald Harmony

12 Night - Wonders of Vietnam, Cambodia & the Mekong
Starting in Ho Chi Minh City, Ho Chi Minh City / Mekong Cruise, Ben Tre, Sa Dec / My An Hung, Gieng Island / An Long, Tan Chau / Vietnam / Cambodia Border Crossing, Phnom Penh, Phnom Penh / Oudong / Prek KDam, Prek KDam Disembarkation / Siem Reap, Siem Reap, Depart Siem Reap
2026 Sails: Feb 26, Mar 12, Mar 26, Apr 9, Apr 23, May 7, More...

Viking River Tours, Viking Saigon Tours

14 Night - Magnificent Mekong
Starting in Hanoi, Siem Reap, Kampong Cham, Phnom Penh, Scenic Sailing : Mekong River, Tan Chau, Sa Dec, Cai Be, Ho Chi Minh City
2026 Sails: Feb 27, Aug 21, Sep 4, Sep 18, Oct 2, Oct 16, Nov 13, Nov 27, Dec 11, Dec 25, 2027: Jan 8, Jan 22, Feb 5, Feb 19, Mar 5, Mar 19, Apr 2, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, Oct 22, Nov 5, More...

<= Back

More =>