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Main River Cruises

River Cruises sailing on the Main River

Click on a cruise ship itinerary sailing on the Main River (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Main River), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name

Cruises on the Main River also sail: Aare River : Amstel River : Corrib River : Dambovita River : Danube River : Douro River : Drava River : Elbe River : Inn River : Isar River : Lake Brienz : Lake Geneva : Lek River : Liffey River : Limmat River : Ljubljanica River : Loch Lomond : Manzanares River : Moselle River : Neckar River : Ness River : Netherlands Waterways : Norway Coast : Ouse River : Reuss River : Rhine River : Rhone River : Roth River : Salzach River : Sava River : Scheldt River : Seine River : Senne River : Spree River : Vltava River : Volkach River : Water of Leith River


Scenic Luxury Cruises, Scenic Jade
Scenic Jade Cruises18 Night - Jewels of Europe with Ljubljana & Zagreb
Starting in Amsterdam, Cologne / Bonn, Rhine Gorge / Rudesheim, Miltenberg / Wertheim, Wurzburg, Bamberg, Nuremberg, Regensburg, Passau / Schlogen, Durnstein / Krems, Vienna, Budapest, Budapest / Ljubljana, Ljubljana, Ljubljana / Zagreb, Zagreb / Plitvice National Park / Zagreb, Zagreb
2026 Sails: Aug 26, 2027: May 7, Jul 30, More...
Scenic Luxury Cruises, Scenic Ruby
Scenic Ruby Cruises28 Night - Romantic Rhine & Moselle with Wonders of Switzerland & Austria
Starting in Amsterdam, Dordrecht, Bruinisse, Antwerp, Arnhem, Dusseldorf, Cochem, Bernkastel, Koblenz, Rudesheim, Mannheim, Strasbourg, Breisach, Basel / Zurich, Zurich, Zurich / Lucerne and Engelberg / Interlaken, Interlaken, Interlaken / Montreux, Montreux, Montreux / Zermatt, Zermatt, Zermatt / Schwangau, Schwangau, Schwangau / Salzburg, Salzburg, Salzburg / Vienna, Vienna
2026 Sails: Aug 26, More...
Emerald Cruises, Emerald Destiny
Emerald Destiny Cruises10 Night - Berlin & the Majestic Rhine
Starting in Berlin, Berlin / Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel
2026 Sails: Aug 28, 2027: Jul 8, More...
Emerald Cruises, Emerald Destiny
Emerald Destiny Cruises13 Night - Berlin to Zurich & the Majestic Rhine
Starting in Berlin, Berlin / Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Lucerne, Lucerne, Lucerne / Zurich, Zurich
2026 Sails: Aug 28, More...
Emerald Cruises, Emerald Destiny
Emerald Destiny Cruises10 Night - Berlin & the Majestic Rhine
Starting in Berlin, Berlin / Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Zurich
2026 Sails: Aug 28, More...
Uniworld Boutique River Cruise Tours, S.S. Beatrice Cruise Tours
S.S. Beatrice Cruise Ship23 Night - Ultimate European Journey
Starting in Bucharest, Bucharest, Transfer to Giurgiu, Ruse, Vidin, Cruising the Iron Gates, Donji Milanovac, Golubac, Belgrade, Ilok, Aljmas, Budapest, Cruising the Danube River, Vienna, Vienna, Cruising the Wachau Valley, Weissenkirchen (Melk), Passau, Regensburg, Nuremberg, Bamberg, Wurzburg (Rothenburg), Wertheim, Frankfurt (Heidelberg), Rudesheim, Cologne, Amsterdam
2026 Sails: Aug 28, More...
Riviera River Cruises, MS Riviera Resplendence
MS Riviera Resplendence Cruises10 Night - Rhine Cruise to Switzerland (Including Glacier Express Extension)
Starting in Cologne, Germany, Rhine River, Koblenz, Germany, Rudesheim, Germany, Speyer, Germany, Rhine River, Basel, Switzerland, Davos, Switzerland, Zermatt, Switzerland
2026 Sails: Aug 29, Sep 12, Sep 26, 2027: Jun 23, Jul 21, Aug 11, More...
Scenic Luxury Cruises, Scenic Jasper
Scenic Jasper Cruises17 Night - Jewels of Europe with Prague
Starting in Prague, Prague / Budapest, Budapest, Vienna, Krems / Durnstein, Brandstatt / Passau, Regensburg, Nuremberg, Bamberg, Wurzburg, Wertheim / Miltenberg, Rudesheim / Rhine Gorge / Bonn, Cologne, Amsterdam
2026 Sails: Aug 29, 2027: Jul 10, Aug 7, Oct 2, More...
AmaWaterways Cruise Tours, AmaCerto Cruise Tours
AmaCerto Cruise Tours13 Night - Europe's Rivers & Castles with Prague Pre-Cruise and Paris Post-Cruise
Starting in Prague, Nuremberg, Bamberg, Wurzburg, Wertheim, Rudesheim, Rhine Gorge, Lahnstein, Cochem, Wasserbillig, Luxembourg, Paris
2026 Sails: Aug 30, Oct 25, 2027: Mar 28, May 9, Jul 18, Aug 29, Oct 10, More...
Emerald Cruises, Emerald Destiny
Emerald Destiny Cruises7 Night - The Majestic Rhine
Starting in Frankfurt / Mainz, Rudesheim, Koblenz, Mannheim / Ludwigshafen / Heidelberg, Rastatt (Baden-Baden), Kehl / Strasbourg, Breisach / Colmar, Basel / Zurich
2026 Sails: Aug 31, 2027: Jul 11, More...

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Main River Cruises