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Syracuse River Cruise Departures

River Cruises that depart from Mediterranean: Italy: Syracuse

See all Cruises that depart from Syracuse

Click on a cruise ship itinerary sailing from Syracuse (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Syracuse), please visit: Cruise Search or try our Virtual Cruise Advisor™.

River cruises by river name


American Lines Tours, American Patriot Tours
American Patriot Tours8 Night - Great Lakes & Thousand Islands Cruise
Starting in Syracuse, NY, Oswego, NY / Day of Cruising, Clayton, NY, Day of Cruising, Ogdensburg, NY, Rochester, NY, Day of Cruising the Welland Canal, Buffalo, NY
2026 Sails: May 22, Jun 5, 2027: May 2, Jun 23, Aug 21, Oct 5, 2028: May 1, Jun 22, Aug 20, Oct 4, More...

Syracuse River Cruise Departures