All Cruise Lines
American Cruise Lines
American Symphony
For help choosing a cruise, try our Virtual Cruise Advisor™ or Live Help.
For cruise/land tour combination itineraries, see American Symphony Tours.
Select a sail date below for competing quotes from multiple travel agencies:
7 Night - Gulf Coast Cruise
Starting in New Orleans, La, Day of Cruising, Gulfport / Ship Island, MS, Biloxi, MS, Ocean Springs, MS, Mobile, Al, Pensacola, FL
2026 Sails: Mar 1, Mar 13, Nov 10, Dec 8, Dec 20, 2027: Feb 12, Feb 24, Mar 8, Mar 20, Apr 1, Dec 10, Dec 22, 2028: Feb 20, Mar 3, Mar 15, Mar 27
7 Night - Gulf Coast Cruise
Starting in Pensacola, FL, Day of Cruising, Mobile, Al, Biloxi, MS, Ocean Springs, MS, Gulfport / Ship Island, MS, New Orleans, La
2026 Sails: Mar 7, Mar 19, Nov 16, Dec 14, Dec 26, 2027: Feb 18, Mar 2, Mar 14, Mar 26, Apr 7, Dec 16, Dec 28, 2028: Feb 26, Mar 9, Mar 21, Apr 2
7 Night - Highlights of the Mississippi Cruise
Starting in New Orleans, La, Cruising the Historic Mississippi River, Oak Alley, LA, Baton Rouge, LA, Natchez / Vicksburg, MS, St Francisville, LA, New Orleans, La
8 Night - Lower Mississippi River Cruise
Starting in New Orleans, La, Cruising the Lower Mississippi River, Oak Alley, LA, St Francisville, LA, Natchez, MS, Vicksburg, MS, Cleveland, MS, Memphis, TN
8 Night - Lower Mississippi River Cruise
Starting in Memphis, TN, Cruising the Lower Mississippi River, Cleveland, MS, Vicksburg, MS, Natchez, MS, St Francisville, LA, Day of River Cruising, Oak Alley, LA, New Orleans, La
8 Night - Music Cities Cruise
Starting in Memphis, TN, Day of River Cruising, Cruising the Ohio River, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Dover TN, Clarksville, TN, Nashville, TN
8 Night - Tennessee Rivers Cruise
Starting in Nashville, TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Savannah, TN, Florence, AL, Decatur, AL, Cruising the Tennessee River, Chattanooga, TN
2026 Sails: Apr 28, May 12, May 26, Jun 9, Jul 21, Sep 15, Sep 29, Oct 13, 2027: Apr 27, May 11, May 25, Jun 8, Oct 15, 2028: Apr 23, May 7, May 21, Jun 4
8 Night - Tennessee Rivers Cruise
Starting in Chattanooga, TN, Cruising the Tennessee River, Decatur, AL, Florence, AL, Savannah, TN, Paducah, KY, Cruising Lake Barkley and the Cumberland River, Nashville, TN
2026 Sails: May 5, May 19, Jun 2, Jun 16, Jul 28, Sep 22, Oct 6, Oct 20, 2027: May 4, May 18, Jun 1, Jun 15, Oct 22, 2028: Apr 30, May 14, May 28, Jun 11
8 Night - Music Cities Cruise
Starting in Nashville, TN, Cruising the Cumberland River, Clarksville, TN, Dover TN, Cruising Lake Barkley and the Cumberland River, Paducah, KY, Day of River Cruising, Memphis, TN
8 Night - Ohio River Cruise
Starting in Louisville, KY, Day of Cruising, Madison, IN, Cincinnati, OH, Day of Cruising, Marietta, OH, Day of Cruising, Pittsburgh, PA
8 Night - Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Wheeling, WV, Marietta, OH, Day of Cruising, Cincinnati, OH, Madison, IN, Louisville, KY
8 Night - Upper Mississippi River Cruise
Starting in St Louis, MO / Alton, IL, Cruising the Mississippi River, Hannibal, MO, Day of Cruising, Muscatine, IA, Dubuque, IA, Winona, MN, Red Wing, MN, St Paul, MN
8 Night - Arkansas River Cruise
Starting in Memphis, TN, Day of Cruising, Cleveland, MS, Day of River Cruising, Little Rock, AR, Fort Smith / Van Buren, AR, Muskogee, OK, Tulsa, OK
2027 Sails: Nov 5
8 Night - Arkansas River Cruise
Starting in Tulsa, OK, Day of Cruising, Muskogee, OK, Fort Smith / Van Buren, AR, Little Rock, AR, Day of River Cruising, Cleveland, MS, Memphis, TN
2027 Sails: Nov 12
13 Night - Mississippi & Ohio Rivers Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Baton Rouge, LA, Day of River Cruising, Natchez, MS, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of Cruising, Paducah, KY, Day of River Cruising, Louisville, KY
15 Night - Mississippi & Cumberland Rivers Cruise
Starting in Nashville, TN, Cruising the Mississippi River, Clarksville, TN, Dover TN, Day of River Cruising, Paducah, KY, Day of Cruising, Memphis, TN, Day of River Cruising, Vicksburg, MS, Natchez, MS, Day of River Cruising, Baton Rouge, LA, Oak Alley, LA, New Orleans, La
15 Night - Grand Ohio River Cruise
Starting in Pittsburgh, PA, Day of Cruising, Marietta, OH, Day of Cruising, Maysville, KY, Cincinnati, OH, Madison, IN, Louisville, KY, Day of Cruising, Henderson, KY / Evansville, IN, Day of Cruising, Paducah, KY, Day of Cruising, St Louis, MO
15 Night - Grand Heartland Cruise
Starting in St Paul, MN, Cruising the Mississippi River, La Crosse, WI, Dubuque, IA, Davenport, IA, Day of Cruising, Hannibal, MO, Day of River Cruising, St Louis, MO, Memphis, TN, Tunica, MS, Day of Cruising, Vicksburg, MS, Natchez, MS, Baton Rouge, LA, New Orleans, La
15 Night - Mississippi & Cumberland Rivers Cruise
Starting in New Orleans, La, Cruising the Mississippi River, Oak Alley, LA, Baton Rouge, LA, Day of River Cruising, Natchez, MS, Vicksburg, MS, Day of River Cruising, Memphis, TN, Day of Cruising, Paducah, KY, Day of River Cruising, Dover TN, Clarksville, TN, Nashville, TN
2028 Sails: Apr 9
About American Symphony
Like her sister ship American Melody, the 175-passenger American Symphony introduces an updated modern interior design, integrating an elegant and refined aesthetic with our tradition for the spacious comfort found aboard all of our ships. Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.
American Symphony also showcases panoramic views throughout, including an impressive four-story glass atrium in the center of the ship. Ranging from 250 to 650 square feet, all of the spacious staterooms offer full-size bathrooms, roomy closets, and private balconies where you can enjoy daily breakfast room service. The new ship also features many spacious lounges, an onboard fitness center, and a yoga studio where you can relax after the day's adventures.
