Spain Cruise Departures

Cruises that depart from Europe: Spain

Cruises that visit Spain

See all River Cruises that depart from Spain

Click on a cruise ship itinerary sailing from Spain (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Spain), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: Alicante : Barcelona : Bilbao : Cadiz : Canary Islands : Ibiza : Madrid : Malaga : Palma de Majorca : Seville : Tarragona : Valencia : Vega de Terron

Crystal Cruises, Crystal Serenity

12 Night - Europe & Mediterranean
Starting in Barcelona, Port Vendres, Villefranche, Porto Venere, Ajaccio (Corsica), Porto Mahon, Palma De Mallorca, Alicante, Malaga (Costa del Sol), Tangier, Cadiz, Lisbon
2026 Sails: Jun 15, More...

Crystal Cruises, Crystal Serenity

6 Night - Europe & Mediterranean
Starting in Barcelona, Port Vendres, Villefranche, Porto Venere, Ajaccio (Corsica), Porto Mahon, Palma De Mallorca
2026 Sails: Jun 15, More...

Cunard Line, Queen Victoria

14 Night - Italy, France and Spain
Starting in Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain, Alghero, Sardinia, Italy, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Stromboli Sail By, IT, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy
2026 Sails: Jun 15, More...

Cunard Line, Queen Victoria

7 Night - Italy, France and Spain
Starting in Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain
2026 Sails: Jun 15, More...

Cunard Line, Queen Victoria

21 Night - Adriatic and Western Mediterranean
Starting in Barcelona, Spain, La Seyne-sur-Mer (for Toulon), France, Livorno (tours to Florence or Pisa), Italy, Ibiza, Spain, Valencia, Spain, Barcelona, Spain, Alghero, Sardinia, Italy, Ajaccio, Corsica, France, Messina Strait, Italy (Transit), Messina, Sicily, Italy, Stromboli Sail By, IT, Salerno (tours to Capri or Pompeii), Italy, Amalfi Coast Sail By, IT, Civitavecchia (tours to Rome), Italy, Messina Strait, Italy (Transit), Cephalonia, Greece, Corfu, Greece, Kotor, Montenegro, Split, Croatia, Trieste, Italy
2026 Sails: Jun 15, More...

Cunard Line, Queen Victoria

2 Night - Southern Europe from Barcelona to La Seyne-sur-Mer
Starting in Barcelona, Spain, La Seyne-sur-mer (for Toulon), France
2026 Sails: Jun 15, More...

MSC Cruises, MSC Opera

10 Night - Mediterranean
Starting in Malaga (Granada), Spain, Cadiz (Seville), Spain, Lisbon (Cascais), Portugal, Alicante, Spain, Mahon, Spain, Olbia, Italy, Genoa (Portofino), Italy, Marseille (Provence), France, Malaga (Granada), Spain
2026 Sails: Jun 15, Jul 5, Jul 15, Jul 25, Aug 4, Aug 14, Aug 24, Sep 3, Sep 13, Sep 23, More...

Costa Cruise Lines, Costa Pacifica

7 Night - Western Mediterranean from Palma De Mallorca
Starting in Palma De Mallorca, Alicante, Olbia (costa Smeralda), Civitavecchia (Rome), Savona, La Seyne (St Tropez), Palma De Mallorca
2026 Sails: Jun 16, More...

Costa Cruise Lines, Costa Smeralda

6 Night - Western Mediterranean from Barcelona
Starting in Barcelona, Palermo, Civitavecchia (Rome), Savona, Marseille, Barcelona
2026 Sails: Jun 16, More...

MSC Cruises, MSC Meraviglia

7 Night - Mediterranean
Starting in Barcelona, Spain, La Goulette, Tunisia, Palermo (Monreale), Italy, Naples (Pompeii), Italy, Livorno (Florence), Italy, Marseille (Provence), France, Barcelona, Spain
2026 Sails: Jun 16, Jun 23, Jun 30, Jul 7, Jul 14, Jul 21, Jul 28, Aug 4, Aug 11, Aug 18, Aug 25, Sep 1, Sep 8, Sep 15, Sep 22, Sep 29, Oct 6, Oct 13, More...

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