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Cape Town Cruise Departures

Cruises that depart from Africa: South Africa: Cape Town

Cruises that visit Cape Town

See all River Cruises that depart from Cape Town

Click on a cruise ship itinerary sailing from Cape Town (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Cape Town), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Cape Town
Shore Excursions

Regent Seven Seas, Seven Seas Voyager
Seven Seas Voyager23 Night - West African Adventure
Starting in Cape Town, Cruising the South Atlantic Ocean, Walvis Bay, Cruising the South Atlantic Ocean, Sao Tome, Cruising the Gulf of Guinea, Lome, Takoradi, Cruising the North Atlantic Ocean, Banjul, Cruising the North Atlantic Ocean, Mindelo (Porto Grande), Cruising the North Atlantic Ocean, Santa Cruz de Tenerife, Santa Cruz de La Palma, Cruising the North Atlantic Ocean, Lisbon
2026 Sails: Feb 28, More...
AmaWaterways Tours, Zambezi Queen Tours
Zambezi Queen Tours9 Night - Discover Africa with Cruise and Land Package : Cape Town, Wildlife Cruise, Victoria Falls
Starting in Cape Town, Victoria Falls, Johannesburg
2026 Sails: Mar 6, Apr 3, May 8, May 15, Jun 12, Jun 26, Jul 3, Jul 24, More...
AmaWaterways Tours, Zambezi Queen Tours
Zambezi Queen Tours15 Night - Stars of South Africa with Cruise and Land Package : Cape Town, Wildlife Cruise, Victoria Falls, Johannesburg, Greater Kruger National Park
Starting in Cape Town, Victoria Falls, Johannesburg, Kruger Park, Johannesburg
2026 Sails: Mar 6, Apr 3, May 8, May 15, Jun 12, Jun 26, Jul 3, Jul 24, More...
Swan Hellenic, SH Diana
SH Diana11 Night - Cruising in Namibia : the Skeleton Coast
Starting in Cape Town, Saldanha Bay, Langebaan, Luderitz, Walvis Bay, Ilha Baia Dos Tigres, Namibe, Luanda
2026 Sails: Mar 25, More...
Silversea, Silver Cloud
Silver Cloud20 Night - Cape Town to Mahe
Starting in Cape Town, Port Elizabeth ZA, Richards Bay, Bazaruto Island, Island of Mozambique, Kilwa Kisiwani, Sinda Island, Misali Island, Zanzibar, Assumption, Aldabra, La Digue, Mahe
2026 Sails: Mar 27, More...
Oceania Cruises, Oceania Sirena
Oceania Sirena24 Night - African Revelation
Starting in Cape Town, Luderitz, Walvis Bay, Sao Tome, Lome, Sekondi / Takoradi, Abidjan, Banjul, Dakar, Mindelo (Sao Vicente), Arrecife (Lanzarote), Agadir, Lisbon
2026 Sails: Mar 31, 2027: Feb 7, More...
AmaWaterways Tours, Zambezi Queen Tours
Zambezi Queen Tours14 Night - Rivers & Rails of Africa with Cape Town, Safari Cruise, Victoria Falls, Rovos Rail
Starting in Cape Town, Victoria Falls, Rovos Rail, Pretoria, Johannesburg
2026 Sails: Apr 3, May 8, Jul 3, More...
MSC Cruises, MSC Opera
MSC Opera5 Night - South Africa
Starting in Cape Town, South Africa, Walvis Bay, Namibia, Cape Town, South Africa
2026 Sails: Apr 4, More...
Cunard Line, Queen Mary 2
Queen Mary 225 Night - Cape Town to New York
Starting in Cape Town, South Africa, Walvis Bay, Namibia, Dakar, Senegal, Tenerife, Spain, Cadiz (tours to Seville), Spain, Southampton, England, UK, Le Havre, France, New York, NY
2026 Sails: Apr 13, More...

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Cape Town Cruise Departures