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St Louis Cruise Departures

Cruises that depart from North America: United States: Missouri: St Louis

Cruises that visit St Louis

See all River Cruises that depart from St Louis

Click on a cruise ship itinerary sailing from St Louis (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just St Louis), please visit: Cruise Search or try our Virtual Cruise Advisor™.


Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2022 Sails: Aug 27, Sep 10, More...
Queen of the Mississippi Cruises10 Night - Mississippi River Gateway Cruise from St. Louis, MO to New Orleans, LA
Starting in St. Louis, MO; with stops in Paducah, KY; New Madrid, MO; Memphis, TN; Vicksburg, MS; Natchez, MS; Baton Rouge, LA; New Orleans, LA
2022 Sails: Oct 5, 2023: Oct 4, More...
American Symphony Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2022 Sails: Oct 8, 2023: Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Sep 29, Oct 13, Oct 27, More...
America Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2022 Sails: Oct 15, 2023: Jul 19, Aug 2, Sep 2, Sep 16, Sep 30, Oct 14, More...
American Queen Cruises8 Night - St. Louis (Alton) to Nashville (Clarksville)
Starting in St. Louis, MO; with stops in Alton, IL; St. Louis, MO; Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Oct 23, 2023: Aug 13, More...
American Countess Cruises8 Night - Star-Spangled Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Bettendorf, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 3, More...
American Countess Cruises8 Night - American Culinary Experience River Cruise from St. Louis to Louisville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2023 Sails: Jul 31, More...
Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2023 Sails: Aug 12, Aug 26, Sep 9, More...
American Queen Cruises8 Night - St. Louis to Memphis
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; New Madrid, MO; Ashport Landing, TN; Memphis, TN
2023 Sails: Aug 27, More...


St Louis Cruise Departures

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