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Santiago Cruise Departures

Cruises that depart from South America: Chile: Santiago

Cruises that visit Santiago

Click on a cruise ship itinerary sailing from Santiago (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Santiago), please visit: Cruise Search or try our Virtual Cruise Advisor™.



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National Geographic Explorer cruise ship17 Night - Antarctica and Patagonia: Legendary Ice and Epic Fjords Roundtrip Cruise from Santiago
Starting in Santiago, Chile; with stops in Ushuaia, Argentina/EMBARK; Drake Passage; Exploring Antarctica; Exploring the Chilean Fjords: Glacier Alley; Tierra del Fuego: Karukinka Natural Park & Bahia Ainsworth; Francisco Coloane Marine Park; Exploring the Chilean Fjords: Kirke Narrows & Puerto Natales; Torres del Paine National Park; Puerto Natales/DISEMBARK; Santiago, Chile
2021 Sails: Nov 3, 2022: Oct 23, More...
MS Roald Amundsen Cruises17 Night - Antarctica, Chilean Fjords and Falklands - Great Explorers and Wildlife 2021/22 Roundtrip from Santiago de Chile
Starting in Santiago de Chile, Flight to Punta Arenas; with stops in Patagonia; Drake Passage; Antarctica; The Falkland Islands; Punta Arenas; Flight to Santiago de Chile
2021 Sails: Nov 8, Dec 10, Dec 26, 2022: Jan 11, Jan 27, Feb 12, Feb 28, More...
National Geographic Resolution Cruises21 Night - Antarctica, South Georgia and the Falklands Roundtrip Cruise from Santiago
Starting in Santiago, Chile; with stops in Ushuaia, Argentina/EMBARK; Antarctica; South Georgia Island; Falkland Islands; Ushuaia/DISEMBARK; Santiago, Chile
2021 Sails: Nov 18, 2022: Feb 6, 2023: Feb 17, More...
MS Roald Amundsen Cruises17 Night - Antarctica, Chilean Fjords and Falklands - Great Explorers and Solar Eclipse Roundtrip from Santiago de Chile
Starting in Santiago de Chile, Flight to Punta Arenas; with stops in Antarctica; South Orkeny Islands; The Falkland Islands; Punta Arenas; Flight to Santiago de Chile
2021 Sails: Nov 24, More...
National Geographic Resolution Cruises11 Night - Journey to Antarctica: The White Continent Roundtrip Cruise from Santiago
Starting in Santiago, Chile; with stops in Ushuaia, Argentina/EMBARK; Crossing the Drake Passage; Exploring Antarctica; Ushuaia/DISEMBARK; Santiago, Chile
2021 Sails: Dec 8, Dec 18, Dec 28, 2022: Jan 7, Jan 27, 2023: Jan 8, Jan 18, Jan 28, Feb 7, More...
Diamond Princess Cruise Tours21 Night - Iguazu Falls Adventure - Tour 1G from Santiago (San Antonio), Chile to Rio De Janeiro, Brazil
Cruise first (16 days), followed by land (5 days) 4 Ports: Santiago (San Antonio), Chile; Punta Arenas, Chile; Ushuaia (Tierra del Fuego), Argentina; Cape Horn (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Falkland Islands (Stanley); Montevideo, Uruguay; Buenos Aires, Argentina; 3 Land Destinations: Buenos Aires, Argentina; Iguazu Falls, Brazil; Rio De Janeiro, Brazil
2021 Sails: Dec 19, More...
Diamond Princess Cruise Tours21 Night - Iguazu Falls Adventure - Tour 1C from Santiago (San Antonio), Chile to Rio De Janeiro, Brazil
Cruise first (16 days), followed by land (5 days) 4 Ports: Santiago (San Antonio), Chile; Punta Arenas, Chile; Ushuaia (Tierra del Fuego), Argentina; Cape Horn (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Antarctic Peninsula (Scenic Cruising); Falkland Islands (Stanley); Montevideo, Uruguay; Buenos Aires, Argentina 3 Land Destinations: Buenos Aires, Argentina; Iguazu Falls, Brazil; Rio De Janeiro, Brazil
2022 Sails: Jan 20, More...
Scenic Eclipse Cruises19 Night - Patagonian Adventure with Antarctica in Depth: Santiago to Buenos Aires aboard Scenic Eclipse (Combo)
Starting in Santiago with stops in Torres del Paine National Park, El Calafate, Ushuaia, Antarctic Peninsula, Buenos Aires
2022 Sails: Jan 29, More...
Azamara Quest Cruise Ship21 Night - Fjords & Antarctica Voyage onboard Azamara Quest
Starting in Santiago with stops in Puerto Montt, Puerto Chacabuco, Chilean Fjords, Punta Arenas, Beagle Channel, Ushuaia, Antarctic Sound/Peninsula, Port Stanley, Puerto Madryn, Montevideo, Buenos Aires
2022 Sails: Feb 2, More...
Diamond Princess Cruise Tours19 Night - Iguazu Falls Adventure - Tour 1B from Santiago (San Antonio), Chile to Rio De Janeiro, Brazil
Cruise first (14 days), followed by land (5 days) 6 Ports: Santiago (San Antonio), Chile; Puerto Montt, Chile; Amalia Glacier, Chile (Scenic Cruising); Punta Arenas, Chile; Ushuaia (Tierra del Fuego), Argentina; Cape Horn (Scenic Cruising); Falkland Islands (Stanley); Puerto Madryn, Argentina; Montevideo, Uruguay; Buenos Aires, Argentina; Buenos Aires, Argentina 3 Land Destinations: Buenos Aires, Argentina; Iguazu Falls, Brazil; Rio De Janeiro, Brazil
2022 Sails: Feb 19, More...


Santiago Cruise Departures

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