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Missouri Cruise Departures

Cruises that depart from North America: United States: Missouri

Cruises that visit Missouri

See all River Cruises that depart from Missouri

Click on a cruise ship itinerary sailing from Missouri (below) and select a sail date to receive competing cruise quotes. To search all cruise itineraries (not just Missouri), please visit: Cruise Search or try our Virtual Cruise Advisor™.

Related areas: St Louis


American Queen Cruises8 Night - American Culinary Experience Cruise from St. Louis to Louisville
Starting in St. Louis, MO; with stops in Alton, IL; Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2022 Sails: Jul 24, More...
American Duchess Cruises8 Night - An American Music Festival River Cruise from St. Louis (Alton) to Nashville (Clarksville)
Starting in St. Louis, MO; with stops in Alton, IL; St. Louis, MO; Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Aug 6, More...
American Countess Cruises8 Night - St. Louis (Alton) to Chicago (Ottawa)
Starting in St. Louis (Alton); with stops in Alton, IL; Hannibal, MO; Grafton, IL; Havana, IL; Peoria, IL; Ottawa, IL
2022 Sails: Aug 8, More...
American Queen Cruises8 Night - St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2022 Sails: Aug 21, Sep 4, Oct 9, 2023: Jul 16, Jul 30, Sep 24, More...
American Countess Cruises8 Night - Quilting the Fabric of America River Cruise from St. Louis to Louisville
Starting in St. Louis, MO; with stops in Chester, IL; Cape Girardeau, MO; Paducah, KY; Henderson, KY; Owensboro, KY; Brandenburg, KY; Louisville, KY
2022 Sails: Aug 22, 2023: Jul 31, More...
Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2022 Sails: Aug 27, Sep 10, More...
American Symphony Cruises7 Night - Upper Mississippi River Cruise from St. Louis, MO to St. Paul, MN
Starting in St. Louis, MO; with stops in Hannibal, MO; Fort Madison, IA; Davenport, IA; Dubuque, IA; Winona, MN; Red Wing, MN; St. Paul, MN
2022 Sails: Oct 8, More...
American Queen Cruises8 Night - St. Louis (Alton) to Nashville (Clarksville)
Starting in St. Louis, MO; with stops in Alton, IL; St. Louis, MO; Chester, IL; Cape Girardeau, MO; Paducah, KY; Dover, TN; Clarksville, TN
2022 Sails: Oct 23, More...
American Countess Cruises8 Night - Star-Spangled Cruise from St. Louis (Alton) to Minneapolis (Red Wing)
Starting in St. Louis, MO; with stops in Alton, IL; Hannibal, MO; Bettendorf, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2023 Sails: Jul 3, More...
Viking Mississippi Cruises7 Night - America's Heartland - St. Louis to St. Paul
Starting in St. Louis with stops in Hannibal, Burlington, Quad Cities, Dubuque, La Crosse, Red Wing, St. Paul
2023 Sails: Aug 12, Aug 26, Sep 9, More...


Missouri Cruise Departures

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