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United States River Cruise Departures

River Cruises that depart from North America: United States

River Cruises that visit United States

See all Cruises that depart from United States

Click on a river cruise ship itinerary sailing from United States (below) and select a sail date to receive competing cruise quotes. To search all river cruise itineraries (not just United States), please visit: Cruise Search.

River cruises by river name

Related areas: Illinois : Kentucky : Louisiana : Minnesota : Missouri : Ohio : Oregon : Pennsylvania : Tennessee : Washington

American Cruise Lines, Queen of the Mississippi
Queen of the Mississippi Cruises10 Night Ohio River Cruise from Pittsburgh, PA to St. Louis
10 Days - Starting in Pittsburgh, PA; with stops in Marietta, OH; Maysville, KY; Cincinnati, OH; Louisville, KY; Henderson, KY; Paducah, KY; Cape Girardeau, MO; St. Louis, MO
2017 Sails: Jun 28, Jul 18, 2018: Jun 27, Jul 17, More...
 
American Cruise Lines, America
America Cruises7 Night Mississippi River from Memphis, TN to New Orleans, LA
7 Days - Starting in Memphis, Tennessee; with stops in Vicksburg, Mississippi; Natchez, Mississippi; St. Francisville, Louisiana; Baton Rouge, Louisiana; Oak Alley, Louisiana; New Orleans, Louisiana
2017 Sails: Jul 1, Nov 18, Dec 2, 2018: Mar 31, Apr 14, Apr 28, May 19, Jun 16, Jun 30, Nov 17, Dec 1, More...
 
American Cruise Lines, American Pride
American Pride Cruises7 Night Columbia and Snake Rivers from Clarkston, WA to Portland, OR
7 Days - Starting in Clarkston, Washington; with stops in Pendleton, Oregon; The Dalles, Oregon; Stevenson, Washington; Rainier, Oregon; Astoria, Oregon; Portland, Oregon
2017 Sails: Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, Oct 10, Oct 24, Nov 7, Nov 21, 2018: Mar 17, Mar 31, Apr 14, May 2, May 16, May 30, Jun 13, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, More...
 
American Cruise Lines, Queen of the West
Queen of the West Cruises7 Nights Columbia and Snake Rivers from Portland, OR to Clarkston, WA
7 Days - Starting in Portland, Oregon; with stops in Astoria, Oregon; Ranier, Oregon; Stevenson, Washington; The Dalles, Oregon; Pendleton, Oregon; Richland, Washington; Clarkston, Washington
2017 Sails: Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, 2018: Apr 22, May 19, Jun 2, Jun 16, Jun 30, Jul 14, Jul 28, Aug 11, Aug 25, Sep 8, Sep 22, More...
 
American Queen Steamboat Company, American Duchess
American Duchess Cruises23 Day The Might Mississippi from New Orleans to Minneapolis
23 Days - Starting in New Orleans, LA; with stops in Nottoway, LA; St. Francisville, LA; Natchez, MS; Vicksburg, MS; Greenville, MS; Memphis, TN; Ashport Landing, TN; New Madrid, MO; Paducah, KY; Cape Girardeau, MO; Chester, IL; St. Louis, MO; Hannibal, MO; Clinton, IA; Dubuque, IA; La Crosse, WI; Red Wing, MN
2017 Sails: Jul 2, More...
 
American Queen Steamboat Company, American Empress
American Empress Cruises9 Day Columbia and Snake River from Clarkston to Portland, OR (Vancouver, WA)
9 Days - Starting in Spokane, WA; with stops in Clarkston, WA; Tri-Cities (Richland), WA; The Dalles, OR; Stevenson, WA; Astoria, OR; Vancouver, WA
2017 Sails: Jul 2, Jul 16, Jul 30, Aug 13, Aug 27, Sep 10, Sep 24, Oct 8, Oct 22, Nov 5, 2018: Apr 8, Apr 22, May 6, May 20, Jun 3, Jun 17, Jul 1, Jul 15, Jul 29, Aug 12, Aug 26, Sep 9, Sep 23, More...
 
American Queen Steamboat Company, American Queen
American Queen Cruises9 Day Ohio-Tennessee River Cruise from Memphis to Louisville
9 Days - Starting in Memphis; with stops in Paducah, KY; Bradenburg, KY; Madison, IN; Louisville, KY
2017 Sails: Jul 2, 2018: Jul 1, More...
 
American Cruise Lines, America
America Cruises4 Night Highlights of the Mississippi River roundtrip from New Orleans, LA
4 Days - Starting in New Orleans, LA; with stops in Houmas House, LA; Baton Rouge, LA; Oak Alley, LA; New Orleans, LA
2017 Sails: Jul 8, Jul 12, Nov 7, 2018: Jul 7, Jul 11, Nov 6, More...
 
American Cruise Lines, American Pride
American Pride Cruises7 Nights Columbia and Snake Rivers from Portland, OR to Clarkston, WA
7 Days - Starting in Portland, Oregon; with stops in Astoria, Oregon; Rainier, Oregon; Stevenson, Washington; The Dalles, Oregon; Pendleton, Oregon; Richland, Washington; Clarkston, Washington
2017 Sails: Jul 8, Jul 22, Aug 5, Aug 19, Sep 2, Sep 16, Oct 17, Oct 31, Nov 14, 2018: Mar 10, Mar 24, Apr 7, Apr 25, May 9, May 23, Jun 6, Jul 7, Jul 21, Aug 4, Aug 18, Sep 1, Sep 15, Oct 16, More...
 
American Cruise Lines, Queen of the Mississippi
Queen of the Mississippi Cruises10 Night Ohio River Cruise from St. Louis to Pittsburgh, PA
10 Days - Starting in St. Louis, MO; with stops in Cape Girardeau, MO; Paducah, KY; Henderson, KY; Louisville, KY; Cincinnati, OH; Maysville, KY; Marietta, OH; Pittsburgh, PA
2017 Sails: Jul 8, 2018: Jun 17, Jul 7, More...
 
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United States River Cruise Departures

 
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